其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Corynantheine CAS Registry Number: 18904-54-6 去氢毛钩藤碱

CAS Name: (16E)-16,17,18,19-Tetradehydro-17-methoxycorynan-16-carboxylic acid methyl ester
Additional Names: (E)-16,17,18,19-tetradehydro-17-methoxy-17,18-secoyohimban-16-carboxylic acid methyl...
Literature References: Isolated from Corynanthe johimbe K. Schum., and Pseudocinchona africana A. Cheval., Rubiaceae: Karrer et al., Helv. Chim. Acta 9, 1059 (1926); 35, 851 (1952). Structure: Janot et al., ibid. 34, 1207 (1951). Stereochemistry: Van Tamelen et al., J. Am. Chem. Soc. 79, 6426 (1957). Total synthesis of dl- form: Van Tamelen, Wright, Tetrahedron Lett. 1964, 295; eidem, J. Am. Chem. Soc. 91, 7349 (1969). Total synthesis of d-form: Autrey, Scullard, ibid. 90, 4917 (1968).

Zingerone CAS Registry Number: 122-48-5 姜酮; 4-(4-羟基-3-甲氧基苯基)-2-丁酮

CAS Name: 4-(4-Hydroxy-3-methoxyphenyl)-2-butanone
Additional Names: (4-hydroxy-3-methoxyphenyl)ethyl methyl ketone; vanillylacetone; zingherone; zingiberone
Percent Composition: C 68.02%, H...
Literature References: Isolated from ginger root or prepd from vanillin and acetone followed by catalytic hydrogenation: Nomura, J. Chem. Soc. 111, 769 (1917); idem, US 1263796 (1918); US 1306710 (1919); Cotton, US 2381210 (1945 to Penn. Coal Prod.); K. Banno, T. Mukaiyama, Bull. Chem. Soc. Jpn. 49, 1453 (1976).

Guaiacol CAS Registry Number: 90-05-1 愈创木酚

CAS Name: 2-Methoxyphenol
Additional Names: methylcatechol; o-hydroxyanisole; 1-hydroxy-2-methoxybenzene
Trademarks: Anastil (Eberth)
Percent Composition: C 67.73%, H 6.50%, O 25.78%
Literature References: Isolated from guaiac resin: Sobrero, Ann. 48, 19 (1843); from hardwood tar: McGinness et al., Tappi 43, 1027 (1960). Prepd by mercuric oxide oxidation of lignin: Lewis, Pearl, US 2433227 (1947 to Sulphite Prod.); by oxidation of anisole with trifluoroperoxyacetic acid: McClure, Williams, J. Org. Chem. 27, 627 (1962); from acetovanillone + ZnCl2: Read, US 3057927 (1962 to Ontario Res. Found.); from the diazonium salt of o-anisidine: Herbst, DE 1148236 (1963 to Hoechst). Toxicity data: Taylor et al., Toxicol. Appl. Pharmacol. 6, 378 (1964).

Cortolone CAS Registry Number: 516-42-7 Β-皮甾酮四醇

CAS Name: (3a,5b,20S)-3,17,20,21-Tetrahydroxypregnan-11-one
Additional Names: 3a,17a,20a,21-pregnanetetrol-11-one
Percent Composition: C 68.82%, H 9.35%, O 21.83%
Literature References: Isolated from human urine after administration of cortisone, hydrocortisone or ACTH: D. K. Fukushima et al., J. Biol. Chem. 212, 449 (1955). Synthesis: L. H. Sarett, J. Am. Chem. Soc. 71, 1169 (1949); A. H. Soloway et al., ibid. 76, 2941 (1954).

Cortol CAS Registry Number: 516-38-1 Alpha-皮甾五醇

CAS Name: (3a,5b,11b,20S)-Pregnane-3,11,17,20,21-pentol
Percent Composition: C 68.44%, H 9.85%, O 21.71%
Literature References: Isolated from human urine after administration of hydrocortisone or ACTH: Fukushima et al., J. Biol. Chem. 212, 449 (1955).

Indican (Plant Indican) CAS Registry Number: 487-60-5 吲哚基 β-D-葡萄糖苷

CAS Name: 1H-Indol-3-yl-b-D-glucopyranoside
Additional Names: 3-(b-glucosido)indole; indoxyl-b-D-glucoside
Percent Composition: C 56.94%, H 5.80%, N 4.74%, O 32.51%
Literature References: Isolated from Indigofera spp., Leguminosae and from Polygonum tinctorium Ait., Polygonaceae. Extraction procedure for the glucoside: Hoogewerff, Meulen, Rec. Trav. Chim. 19, 166 (1900); Perkin, Bloxam, J. Chem. Soc. 91, 1715 (1907); Perkin, Thomas, ibid. 95, 793 (1909). About 3% indican is found in 4-day old air-dried leaves of Indigofera tinctoria. Synthesis: Robertson, J. Chem. Soc. 1927, 1937; Robertson, Waters, ibid. 1933, 30; Freudenberg et al., Ber. 85, 641 (1952).

Filicinic Acid CAS Registry Number: 2065-00-1 2,2-二甲基环己烷-1,3,5-三酮

CAS Name: 3,5-Dihydroxy-4,4-dimethyl-2,5-cyclohexadien-1-one
Additional Names: 1,1-dimethylcyclohexane-2,4,6-trione; gem-dimethylphloroglucinol; filicinsäure (German)
Percent Composition: C ...
Literature References: Isolated from male fern and by hydrolytic decompn of filixic acid or aspidin: Boehm, Ann. 302, 171 (1898); 329, 321 (1903). Synthesis: Robertson, Sandrock, J. Chem. Soc. 1933, 1617; Angus et al., Chem. Ind. (London) 1954, 546; Inagaki et al., J. Pharm. Soc. Jpn. 76, 1258 (1956); Hoefer, Riedl, Angew. Chem. 74, 501 (1962); eidem, Ann. 656, 127 (1962).

Sabadine CAS Registry Number: 124-80-1 乙種藜蘆鹼

CAS Name: (3b,4a,16b)-Cevane-3,4,12,14,16,17,20-heptol 3-acetate
Additional Names: sabatine
Percent Composition: C 64.78%, H 8.81%, N 2.60%, O 23.80%
Literature References: Isolated from Sabadilla seed: Merck, Arch. Pharm. 229, 164 (1891); Hennig et al., J. Am. Pharm. Assoc. 40, 168 (1951). Structure: Auterhoff, Schwartz, Arch. Pharm. 288, 549 (1955); Möhrle, Auterhoff, ibid. 292, 337 (1959); Kupchan et al., J. Med. Pharm. Chem. 5, 690 (1962). NMR data: Ito et al., Tetrahedron 20, 913 (1964).

Olivacine CAS Registry Number: 484-49-1 1,5-二甲基-6H-吡啶并[4,3-b]咔唑

CAS Name: 1,5-Dimethyl-6H-pyrido[4,3-b]carbazole
Additional Names: guatambuinine
Percent Composition: C 82.90%, H 5.73%, N 11.37%
Literature References: Isolated from the bark and stem of Aspidosperma olivaceum Müll. Arg., A. australe Müll. Arg., A. longepetiolatum Kuhlm., Apocynaceae: Schmutz, Hunziger, Pharm. Acta Helv. 33, 341 (1958). Identity with guatambuinine: Marini-Bettolo, Carvalho-Ferreira, Ann. Chim. 49, 869 (1959). Structure: Marini-Bettolo, Schmutz, Helv. Chim. Acta 42, 2146 (1959); Ondetti, Deulofeu, Tetrahedron 15, 160 (1961). Synthesis: Schmutz, Wittwer, Helv. Chim. Acta 43, 793 (1960); Wenkert, Dave, J. Am. Chem. Soc. 84, 94 (1962); Mosher et al., J. Med. Chem. 9, 237 (1966); R. Besselievre, H. Husson, Tetrahedron Lett. 1976, 1873; J. Bergman, R. Carlsson, ibid. 1978, 4055; J. P. Kutney et al., Heterocycles 16, 1469 (1981).

Cinobufotalin CAS Registry Number: 1108-68-5 华蟾毒它灵

CAS Name: (3b,5b,15b,16b)-16-(Acetyloxy)-14,15-epoxy-3,5-dihydroxybufa-20,22-dienolide
Additional Names: 14,15b-epoxy-3b,5,16b-trihydroxy-5b-bufa-20,22-dienolide 16-acetate
Percent Compositi...
Literature References: Isolated from the Chinese drug Ch'an Su which is prepd from Chinese toads (Bufo asiaticus = bufo gargarizans Cantor). Isoln: Kotake, Kuwada, C.A. 31, 70652 (1937); Ruckstubl, Meyer, Helv. Chim. Acta 40, 1270 (1957). Structure: Bernoulli et al., ibid. 45, 240 (1962).