其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Metralindole CAS Registry Number: 54188-38-4 美曲吲哚

CAS Name: 2,4,5,6-Tetrahydro-9-methoxy-4-methyl-1H-3,4,6a-triazafluoranthene
Additional Names: 3-methyl-8-methoxy-3H-1,2,5,6-tetrahydropyrazino[1,2,3-ab]-b-carboline
Percent Composition: C 7...
Literature References: Heterocyclic b-carboline derivative used as an antidepressant. Prepn: R. G. Glushkov et al., DE 2357320; eidem, US 4088647 (1974, 1978 both to All Union Khim.-Farm Instit. USSR); eidem, Khim. Farm. Zh. 16, 1054 (1982), C.A. 98, 53831b (1983). Psychotropic activity, toxicity: M. D. Mashkovsky et al., DE 2356091; eidem, US 3959470 (1974, 1976 both to All Union Khim.-Farm. Instit. USSR). Pharmacology: N. I. Andreeva, M. D. Mashkovsky, Farmakol. Toksikol. (Moscow) 43, 133 (1980). Effect on the EEG of the brain cortex: L. F. Roshchina, ibid. 349. Effect on adrenergic neurotransmission: L. V. Panasiuk et al., ibid. 45, 13 (1982). Clinical studies: M. D. Mashkovsky, N. I. Andreeva, Zh. Nevropatol. Psikhiatr. 84, 410 (1984).

EDDS CAS Registry Number: 186459-75-6

CAS Name: N,N'-1,2-Ethanediylbisaspartic acid
Additional Names: ethylenediamine N,N'-disuccinic acid
Percent Composition: C 41.10%, H 5.52%, N 9.59%, O 43.80%
Literature References: Hexadentate chelating agent with 2 chiral centers; structural isomer of EDTA, q.v. S,S-form is naturally occurring and biodegradable. Prepn: M. Barbier et al., Ann. 668, 132 (1963). See also: C. Kezerian, W. M. Ramsey, US 3158635 (1964 to Stauffer). Synthesis and metal chelating behavior of S,S-form: J. A. Neal, N. J. Rose, Inorg. Chem. 7, 2405 (1968); of isomers: M. Orama et al., J. Chem. Soc. Dalton Trans. 2002, 4644. Bacterial production of S,S-form: R. Takahashi et al., Biosci. Biotech. Biochem. 63, 1269 (1999). Crystal structure of S,S-form: F. E. Scarbrough, D. Voet, Acta Crystallogr. B32, 2715 (1976). Biodegradation analysis of isomers: R. Takahashi et al., Biosci. Biotech. Biochem. 61, 1957 (1997); of S,S-form: P. C. Vandevivere et al., Environ. Sci. Technol. 35, 1765 (2001). HPLC determn of S,S-form: S. Tandy et al., J. Chromatogr. A 1077, 37 (2005). Study of use in radiochemical decontamination: P. W. Jones, D. R. Williams, Appl. Radiat. Isot. 54, 587 (2001); in heavy metal phytoextraction from soil: H. Grcman et al., J. Environ. Qual. 32, 500 (2003); E. Meers et al., Chemosphere 58, 1011 (2005).

BBOT CAS Registry Number: 7128-64-5 荧光增白剂OB

CAS Name: 2,2'-(2,5-Thiophenediyl)bis[5-(1,1-dimethylethyl)benzoxazole]
Additional Names: 2,5-bis(5-tert-butyl-2-benzoxazolyl)thiophene; C.I. Fluorescent Brightener 184
Trademarks: Uvitex OB...
Literature References: High mol wt fluorescent whitening agent. Prepn: P. Liechti et al., CH 427822 (1967 to Ciba); Z. Seha, C. D. Weis, Helv. Chim. Acta 63, 413 (1980). Fluorescence depolarization studies: G. R. Fleming et al., Chem. Phys. Lett. 51, 399 (1977). Photostability study: G. Tury et al., J. Photochem. Photobiol. A 114, 51 (1998).

Solanesol CAS Registry Number: 13190-97-1 茄尼醇; 茄呢醇; 九聚异戌二烯醇

CAS Name: (2E,6E,10E,14E,18E,22E,26E,30E,)-3,7,11,15,19,23,27,31,35-Nonamethyl-2,6,10,14,18,22,26,30,34-hexatriacontanonaen-1-ol
Additional Names: nonaisoprenol
Percent Composition: C 85.65%...
Literature References: High molecular weight isoprenoid alcohol isolated from tobacco leaf. Associated with the particulate fraction of tobacco smoke. Isoln: R. L. Rowland et al., J. Am. Chem. Soc. 78, 4680 (1956). Synthesis: R. Rüegg et al., Helv. Chim. Acta 43, 1745 (1960). Stereoselective synthesis: K. Sato et al., J. Chem. Soc. Perkin Trans. 1 1981, 761. Structural analysis: N. J. Jensen, T. Sumpter, Beitr. Tabakforsch. Int. 16, 85 (1995). Determn in tobacco smoke: M. W. Ogden, K. C. Maiolo, LC-GC 10, 459 (1992); in tobacco extracts: K. Z. Liu et al., Anal. Lett. 31, 1947 (1998).

Piretanide CAS Registry Number: 55837-27-9 吡咯他尼

CAS Name: 3-(Aminosulfonyl)-4-phenoxy-5-(1-pyrrolidinyl)benzoic acid
Additional Names: 4-phenoxy-3-(1-pyrrolidinyl)-5-sulfamoylbenzoic acidTrademarks: Diumax (Cusi-Norte); Eurelix (Hoechst); Ta...
Literature References: High-ceiling loop diuretic, structurally related to bumetanide, q.v. Prepn: D. Bormann et al., DE 2419970; eidem, US 4010273 (1975, 1977 both to Hoechst). Chemistry and pharmacology: W. Merkel et al., Eur. J. Med. Chem. 11, 399 (1976). Diuretic activity in man: N. Pozet et al., Br. J. Clin. Pharmacol. 9, 577 (1980); T. Saruta, E. Kato, Arzneim.-Forsch. 30, 1807 (1980). Vascular effects of piretanide: E. Klaus et al., ibid. 33, 1273 (1983); renal effects: M. Omosu et al., ibid. 1277. Review of pharmacology and therapeutic efficacy: S. P. Clissold, R. N. Brogden, Drugs 29, 489-530 (1985).

Muzolimine CAS Registry Number: 55294-15-0 氯唑啉胺

CAS Name: 5-Amino-2-[1-(3,4-dichlorophenyl)ethyl]-2,4-dihydro-3H-pyrazol-3-one
Additional Names: 3-amino-1-(3,4-dichloro-a-methylbenzyl)-2-pyrazolin-5-oneTrademarks: Edrul (Bayer)
Percent Co...
Literature References: High-ceiling loop diuretic. Prepn: E. Möller et al., DE 2319278; eidem, US 3957814 (1974, 1976 both to Bayer); eidem, Experientia 33, 382 (1977). In vitro effects: H. J. Kramer, Pharmatherapeutica 1, 353 (1977). Mechanism of action: M. Mussche, N. Lameire, Curr. Med. Res. Opin. 4, 462 (1977). Pharmacology: K. Meng et al., ibid. 555. Pharmacokinetics: O. Broers et al., Eur. J. Clin. Pharmacol. 15, 105 (1979); eidem, Curr. Med. Res. Opin. 6, 431 (1980). Use in advanced renal disease: A. D. Canton et al., Br. Med. J. 282, 595 (1981); P. Schmidt et al., Eur. J. Clin. Pharmacol. 20, 23 (1981). Toxicological studies: D. Lorke, P. Mürmann, Curr. Med. Res. Opin. 4, 716 (1977). Symposium on pharmacology, pharmacodynamics, toxicology, clinical studies: Clin. Nephrol. 19, Suppl. 1, S1-S117 (1983).

Herrmann-Beller Catalyst CAS Registry Number: 172418-32-5 反式二-(m)-双[2-(二邻甲苯基膦)苄基]乙酸二钯(II)

CAS Name: Bis[m-(acetato-kO:kO')]bis[[2-[bis(2-methylphenyl)phosphino-kP]phenyl]methyl-kC]dipalladium stereoisomer
Additional Names: trans-di(m-acetato)bis[o-(di-o-tolylphosphino)benzyl]dipalla...
Literature References: Highly efficient palladacycle catalyst; exists in a monomer/dimer equilibrium in soln. Prepn: M. Beller et al., DE 4421753 (1995 to Hoechst); eidem, US 5831107 (1998 to Aventis); and catalytic applications: W. A. Herrmann et al., Angew. Chem. Int. Ed. 34, 1844 (1995); eidem, Chem. Eur. J. 3, 1357 (1997); W. A. Herrmann et al., J. Chem. Educ. 77, 92 (2000). EXAFS characterization: S. G. Fiddy et al., Chem. Commun. 2003, 2682. Catalysis mechanism in the Heck reaction: V. P. W. Böhm, W. A. Herrmann, Chem. Eur. J. 7, 4191 (2001). Review of catalytic applications: A. Speicher et al., J. Prakt. Chem. 341, 605-608 (1999).

Deaminooxytocin CAS Registry Number: 113-78-0 去氨缩宫素

CAS Name: 1-(3-Mercaptopropanoic acid)oxytocin
Additional Names: demoxytocin; desaminooxytocinTrademarks: Sandopart (Novartis)
Percent Composition: C 52.05%, H 6.60%, N 15.53%, O 19.35%, S 6...
Literature References: Highly potent analog of the posterior pituitary hormone oxytocin, q.v., differing in structure at the 1 position where the free amino group in the half-cystine residue is replaced by hydrogen. Synthesis and biological activity: du Vigneaud et al., J. Biol. Chem. 235, P.C. 64 (1960); Hope et al., ibid. 237, 1563 (1962); Takashima et al., J. Am. Chem. Soc. 90, 1323 (1968). Isoln and purifn: Ferrier et al., J. Biol. Chem. 240, 4264 (1965). Structure-activity correlation: Jarvis, du Vigneaud, Science 143, 545 (1964). Synthesis of D-isomer: G. Flouret, V. du Vigneaud, J. Med. Chem. 14, 556 (1971). Crystal structure analysis: S. P. Wood et al., Science 232, 633 (1986). Pharmacology and comparison with oxytocin: Chan, du Vigneaud, Endocrinology 71, 977 (1962). Review: Adv. Exp. Med. Biol. vol. 2, 53-104 (1968).

Brassard's Diene CAS Registry Number: 90857-62-8 (E-form); 74272-66-5 (stereo unspecified)

CAS Name: [[(1E)-1,3-Dimethoxy-1,3-butadienyl]oxy]trimethylsilane
Additional Names: 1,3-dimethoxy-1-trimethylsiloxy-1,3-butadiene
Percent Composition: C 53.43%, H 8.97%, O 23.72%, Si 13.88%
Literature References: Highly reactive nucleophilic silyloxydiene; cf. Danishefsky's diene. Prepn: J. Savard, P. Brassard, Tetrahedron Lett. 20, 4911 (1979); eidem, Tetrahedron 40, 3455 (1984). Synthetic applications: M. M. Midland, R. W. Koops, J. Org. Chem. 55, 5058 (1990); T. Ito et al., Tetrahedron Lett. 34, 6583 (1993); Q. Fan et al., Eur. J. Org. Chem. 2005, 3542; of polymer-supported derivatives: C. Pierres et al., Tetrahedron Lett. 44, 3645 (2003).

Diacetone Acrylamide CAS Registry Number: 2873-97-4 双丙酮丙烯酰胺

CAS Name: N-(1,1-Dimethyl-3-oxobutyl)-2-propenamide
Additional Names: N-(1,1-dimethyl-3-oxobutyl)acrylamide; N-[2-(2-methyl-4-oxopentyl)]acrylamide
Percent Composition: C 63.88%, H 8.93%, N ...
Literature References: Highly reactive vinyl monomer. Prepd by the reaction of acrylonitrile with acetone in presence of conc sulfuric acid: Coleman et al., J. Polym. Sci. 3A, 1601 (1965); Coleman, US 3277056 (1966 to Lubrizol). Toxicity data: K. Hashimoto et al., Arch. Toxicol. 47, 179 (1981). Review: idem, "N-Oxoalkylacrylamides" in Encyclopedia of Polymer Science and Technology vol. 15, N. M. Bikales, Exec. Ed. (Wiley-Interscience, New York, 1971) pp 353-364.