其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Prothioconazole CAS Registry Number: 178928-70-6 丙硫菌唑

CAS Name: 2-[2-(1-Chlorocyclopropyl)-3-(2-chlorophenyl)-2-hydroxypropyl]-1,2-dihydro-3H-1,2,4-triazole-3-thione
Additional Names: 2-(1-chlorocyclopropyl)-1-(2-chlorophenyl)-3-(5-mercapto-1,2,4-...
Literature References: Fungal sterol demethylation inhibitor. Prepn: M. Jautelat et al., DE 19528046; eidem, US 5789430 (1996, 1998 both to Bayer). Comprehensive description: A. Mauler-Machnik et al., BCPC Conf. - Pests Dis. 2002, 389-394.

Fumigatin CAS Registry Number: 484-89-9 烟曲霉醌

CAS Name: 3-Hydroxy-2-methoxy-5-methyl-2,5-cyclohexadiene-1,4-dione
Additional Names: 3-hydroxy-2-methoxy-5-methyl-p-benzoquinone; 6-hydroxy-5-methoxy-p-toluquinone; 3-hydroxy-4-methoxy-2,5-tol...
Literature References: Fungal toxin with antibiotic properties isolated from metabolism soln of Aspergillus fumigatus Fres: Anslow, Raistrick, Biochem. J. 32, 687 (1938); Waksman, Geiger, J. Bacteriol. 47, 391 (1944). Synthesis: Baker, Raistrick, J. Chem. Soc. 1941, 670; Posternak, Ruelius, Helv. Chim. Acta 26, 2045 (1943); Seshadri, Venkatasubramanian, J. Chem. Soc. 1959, 1660. Biosynthesis: Pettersson, Acta Chem. Scand. 17, 1323 (1963); Simonart, Verachtert, Bull. Soc. Chim. Biol. 49, 543 (1967). Formation and polarographic assay: J. Lafond-Grellety et al., Ann. Microbiol. 129B, 3 (1978). Review: Wilson, "Miscellaneous Aspergillus Toxins," in Microbial Toxins vol. VI, A. Ciegler et al., Eds. (Academic Press, New York, 1971) p 281.

Furametpyr CAS Registry Number: 123572-88-3 呋吡菌胺

CAS Name: 5-Chloro-N-(1,3-dihydro-1,1,3-trimethyl-4-isobenzofuranyl)-1,3-dimethyl-1H-pyrazole-4-carboxamide
Additional Names: N-(1,1,3-trimethyl-2-oxa-4-indanyl)-5-chloro-1,3-dimethylpyrazole-4...
Literature References: Fungicide developed to control rice sheath blight. Prepn: T. Mori et al., EP 315502; eidem, US 4877441 (1989, 1989 both to Sumitomo). In vitro and in vivo metabolism studies: H. Nagahori et al., J. Agric. Food Chem. 48, 5754 (2000); eidem, ibid. 5760. Brief description: Y. Oguri, Agrochem. Jpn. 1997, no. 70, 15-16.

Zoxamide CAS Registry Number: 156052-68-5 苯酰菌胺

CAS Name: 3,5-Dichloro-N-(3-chloro-1-ethyl-1-methyl-2-oxopropyl)-4-methylbenzamide
Additional Names: N-[3'-(1'-chloro-3'-methyl-2'-oxopentan)]-3,5-dichloro-4-methylbenzamideTrademarks: Zoxium (...
Literature References: Fungicide for foliar use on potatoes, vines and vegetables, targeting Oomycete fungi. Prepn: E. L. Michelotti, D. H. Young, US 5304572 (1994 to Rohm and Haas); H. L. Rayle, L. Fellmeth, Org. Process Res. Dev. 3, 172 (1999). Comprehensive description: A. R. Egan et al., Brighton Crop Prot. Conf. - Pests Dis. 1998, 335-342. Mode of action: D. H. Young, R. A. Slawecki, Pestic. Biochem. Physiol. 69, 100 (2001). Laboratory resistance risk study: D. H. Young et al., Pest Manage. Sci. 57, 1081 (2001).

Gladiolic Acid CAS Registry Number: 478-05-7 4-甲氧-5-甲鄰二醛苯甲酸

CAS Name: 2,3-Diformyl-6-methoxy-5-methylbenzoic acid
Additional Names: 4-methoxy-5-methyl-o-phthalaldehyde-3-carboxylic acid
Percent Composition: C 59.46%, H 4.54%, O 36.00%
Literature References: Fungistatic antibiotic produced by Penicillium gladioli Machacek: Brian et al., Nature 157, 697 (1946). Active only in the form shown; the lactol form, 4-formyl-3-hydroxy-7-methoxy-6-methylphthalide, is inactive. Structure: Grove, Biochem. J. 50, 648 (1952); 54, 664 (1953); J. Chem. Soc. 1952, 3345; Raistrick, Ross, Biochem. J. 50, 635 (1952). Synthesis: Brown, Newbold, J. Chem. Soc. 1954, 1076.

Cicletanine CAS Registry Number: 89943-82-8 西氯他宁

CAS Name: 3-(4-Chlorophenyl)-1,3-dihydro-6-methylfuro[3,4-c]pyridin-7-ol
Additional Names: 1,3-dihydro-3-(4-chlorophenyl)-7-hydroxy-6-methylfuro[3,4-c]pyridine; cicletanide; cycletanide
Perc...
Literature References: Furopyridine derivative with antihypertensive and diuretic properties. Prepn: A. Esanu, BE 891797; idem, US 4383998 (1982, 1983 both to Soc. Conseils Recher. Sci.). Studies on mechanism of action: P. Braquet et al., Lancet 1, 1218 (1983); G. R. Elliott et al., Thromb. Res. 33, 549 (1984). Cardiovascular pharmacology in dogs: R. Jouve et al., J. Cardiovasc. Pharmacol. 8, 208 (1986). In vitro comparison of antihistaminic activity of isomers: P. Schoeffter et al., Eur. J. Pharmacol. 136, 235 (1987). HPLC determn in biological fluids: G. Cuisinaud et al., J. Chromatogr. 341, 97 (1985). Effect on human prostaglandin metabolism: P. Guinot, J. C. Frölich, Arzneim.-Forsch. 35, 1714 (1985). Effect on potassium ion transport in hypertensive patients: R. Garay et al., J. Hypertens. 4, Suppl. 5, S208 (1986). Pharmacokinetics in humans: J. M. Lize et al., Therapie 42, 399 (1987).

Progabide CAS Registry Number: 62666-20-0 普罗加比

CAS Name: 4-[[(4-Chlorophenyl)(5-fluoro-2-hydroxyphenyl)methylene]amino]butanamide
Additional Names: 4-[[a-(p-chlorophenyl)-5-fluorosalicylidene]amino]butyramide; 4-[[a-(p-chlorophenyl)-5-fluor...
Literature References: Gamma-aminobutyric acid (GABA) antagonist with anti-epileptic activity. Prepn: J.-P. Kaplan et al., DE 2634288; eidem, US 4094992 (1977, 1978 to Synthelabo); eidem, J. Med. Chem. 23, 702 (1980). Use as analgesic: J.-P. Kaplan, US 4361583 (1982 to Synthelabo). Pharmacokinetics: I. Johno et al., J. Pharm. Sci. 71, 633 (1982). HPLC determn in biological fluids: P. Padovani et al., J. Chromatogr. 308, 229 (1984). Double-blind clinical trial in therapy resistant epilepsy: P. Loiseau et al., Epilepsia 24, 703 (1983); in spasticity: K. Mondrup, E. Pedersen, Acta Neurol. Scand. 69, 200 (1984).

Pentamethonium Bromide CAS Registry Number: 541-20-8 五甲溴铵

CAS Name: N,N,N,N',N',N'-Hexamethyl-1,5-pentanediaminium bromide
Additional Names: pentamethylenebis[trimethylammonium bromide]; a,w-bis(trimethylammonium)pentane dibromide; 1,5-dibromohexameth...
Literature References: Ganglion blocking agent.

Spherophysine CAS Registry Number: 25978-54-5

CAS Name: N-(4-Aminobutyl)-N-(3-methyl-2-butenyl)guanidine
Additional Names: sphaerophysine
Percent Composition: C 60.57%, H 11.18%, N 28.25%
Literature References: Ganglion blocking agent. Isolated from the following Central Asiatic Leguminosae: Swainsona salsula (Pall.) Taub. (Sphaerophysa salsula (Pall.) DC.); Smirnowia turkestana Bunge; Eremosparton flaccidum Litw.: Rubinshtein, Menshikov, J. Gen. Chem. USSR 14, 161 (1944); Rjabinin, ibid. 17, 2265 (1947); Merlis, ibid. 22, 347 (1952). Structure: Heesing, Eckard, Ber. 103, 534 (1970).

Azamethonium Bromide CAS Registry Number: 306-53-6 阿扎溴铵

CAS Name: 2,2'-(Methylimino)bis[N-ethyl-N,N-dimethylethanaminium]dibromide
Additional Names: [(methylimino)diethylene]bis[ethyldimethylammonium bromide]; 3-methyl-3-azapentane-1,5-bis(ethyldime...
Literature References: Ganglion blocking agent. Prepd from pentamethyl diethylenetriamine and ethyl bromide: Marxer, Miescher, Helv. Chim. Acta 34, 924 (1951); CH 284212 C.A. 48, 7625 (1954); US 2654785 (1952, 1953 both to Ciba). Pharmacological and toxicity studies: H. J. Bein, R. Meier, Experientia 6, 351 (1950); eidem, Schweiz. Med. Wochenschr. 81, 446 (1951); I. V. Uranov, Farmakol. Toksikol. 21, 110 (1958).