其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

TDCPP CAS Registry Number: 13674-87-8 磷酸三(1,3-二氯-2-丙基)酯

CAS Name: 1,3-Dichloro-2-propanol phosphate (3:1)
Additional Names: phosphoric acid tris(1,3-dichloro-2-propyl)ester; tris(1,3-dichloroisopropyl)phosphate; tris[2-chloro-1-(chloromethyl)ethyl]p...
Literature References: Flame retardant formerly used in children's sleepwear; once considered as a potential replacement for Tris-BP, q.v. Prepn: W. J. Jones et al., J. Chem. Soc. 1946, 824. Use in flameproofing: R. J. Polacek, US 3041293 (1962 to Celanese). Thermal studies: K. Paciorek et al., Am. Ind. Hyg. Assoc. J. 39, 633 (1978); N. Inagaki et al., J. Appl. Polym. Sci. 21, 217 (1977); 24, 1 (1979). Mutagenicity studies: M. D. Gold et al., Science 200, 785 (1978); A. Nakamura et al., Mutat. Res. 66, 373 (1979); D. Brusick et al., J. Environ. Pathol. Toxicol. 3, 207 (1979). Toxicity study: J. K. Piotrowski et al., Bromatol. Chem. Toksykol. 9, 141 (1976), C.A. 85, 104825u (1976).

Flavopiridol CAS Registry Number: 146426-40-6 夫拉平度

CAS Name: rel-(-)-2-(2-Chlorophenyl)-5,7-dihydroxy-8-[(3R,4S)-3-hydroxy-1-methyl-4-piperidinyl]-4H-1-benzopyran-4-one
Additional Names: cis-(-)-2-(2-chlorophenyl)-5,7-dihydroxy-8-[4'-(3'-hydrox...
Literature References: Flavone inhibitor of cyclin-dependent kinases; the (-)-cis form induces apoptosis in certain tumor cells. Prepn: S. L. Kattige et al., EP 241003; eidem, US 4900727 (1987, 1990 both to Hoechst). Properties and formulation study: R.-M. Dannenfelser et al., PDA J. Pharm. Sci. Technol. 50, 356 (1996). Mode of action study: S. Brüsselbach et al., Int. J. Cancer 77, 146 (1998). Clinical evaluation in refractory cancers: A. M. Senderowicz et al., J. Clin. Oncol. 16, 2986 (1998). Clinical pharmacokinetics: J. P. Thomas et al., Cancer Chemother. Pharmacol. 50, 465 (2002). Review of chemistry, pharmacology, and antitumor spectrum: H. H. Sedlacek et al., Int. J. Oncol. 9, 1143-1168 (1996).

Catechin CAS Registry Number: 154-23-4 儿茶精; 儿茶素; (2R,3S)-2-(3,4-二羟基苯基)-3,4-二氢-2H-苯并吡喃-3,5,7-三醇

CAS Name: (2R-trans)-2-(3,4-Dihydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-3,5,7-triol
Additional Names: catechol; 3,3',4',5,7-flavanpentol; catechinic acid; catechuic acid; (+)-cyanidanol-3; dex...
Literature References: Flavonoid found primarily in higher woody plants as (+)-catechin along with (-)-epicatechin (cis form). From catechu (gambir and acacia), mahogany wood, etc.: Perkin, Yoshitake, J. Chem. Soc. 81, 1160 (1902); Freudenberg et al., Ber. 55, 1734 (1922). Structure: Freudenberg et al., Ann. 444, 135 (1925). Stereochemistry: Clark-Lewis, Chem. Ind. (London) 1955, 1218; Hardegger et al., Helv. Chim. Acta 40, 1819 (1957); Clark-Lewis, J. Chem. Soc. 1960, 2433. Pharmacology: Van Cauwenberge et al., C.R. Seances Soc. Biol. Ses Fil. 165, 1195 (1971). Metabolism: Das, Sothy, Biochem. J. 125, 417 (1971); and absorption in human: N. P. Das, Biochem. Pharmacol. 20, 3435 (1971). Biosynthesis of epicatechins: Zaprometov, Grisebach, Z. Naturforsch. 28c, 113 (1973). Other catechins such as afzelechin and gallocatechin and catechin oligomers (procyanidins) also exist in nature: Thompson et al., J. Chem. Soc. Perkin Trans. 1 1972, 1287. See also Bioflavonoids.

Sulfuretin CAS Registry Number: 120-05-8 硫黄菊素

CAS Name: (Z)-2-[(3,4-Dihydroxyphenyl)methylene]-6-hydroxy-3(2H)-benzofuranone
Additional Names: 2-(3,4-dihydroxybenzylidene)-6-hydroxy-3(2H)-benzofuranone; 3',4',6-trihydroxyaurone; 3',4',6-tr...
Literature References: Flavonoid pigment responsible for the yellow color of certain species of Compositae. Isoln from Cosmos sulphureus Cav., Compositae: Shimokoriyama, Hattori, J. Am. Chem. Soc. 75, 1900 (1953); from Dahlia variabilis Desf., Compositae: Nordström, Swain, Arch. Biochem. Biophys. 60, 329 (1956). Prepn by condensation of 6-hydroxy-3-coumaranone and protocatechuic alcohol: Nordström, Swain, ibid. Prepn and structure studies: Geissman, Jurd, J. Am. Chem. Soc. 76, 4475 (1954); Farkas et al., Ber. 92, 2847 (1959). Structure: Shimokoriyama, Geissman, J. Org. Chem. 25, 1956 (1960).

Fura-2 CAS Registry Number: 96314-98-6

CAS Name: 2-[6-[Bis(carboxymethyl)amino]-5-[2-[2-[bis(carboxymethyl)amino]-5-methylphenoxy]ethoxy]-2-benzofuranyl]-5-oxazolecarboxylic acid
Percent Composition: C 54.29%, H 4.24%, N 6.55%, O 34...
Literature References: Fluorescent calcium imaging agent; structurally related to BAPTA, q.v. Ca2+ binding causes a spectral shift to shorter wavelengths; ratio of the fluorescence at each wavelength is related to changes in Ca2+ binding and is independent of dye concentration. Also used as pentaacetoxymethyl ester, Fura-2/AM, to enhance crossing of membranes. Prepn: G. Grynkiewicz et al., J. Biol. Chem. 260, 3440 (1985). Binding kinetics to Ca2+: A. P. Jackson et al., FEBS Lett. 216, 35 (1987). Determn of Kd: D. L. Groden et al., Cell Calcium 12, 279 (1991). Spectra of intracellular forms: C. S. Owen, ibid. 385. Photophysics: V. Van den Bergh et al., Biophys. J. 68, 1110 (1995). HPLC determn: M. Castle, E. Neuteboom, J. Chromatogr. A 696, 93 (1995). Determn in tissue: N. N. P. Tran et al., Cell Calcium 18, 420 (1995). Practical aspects of use in intracellular Ca2+ measurement: K. R. Sipido, G. Callewaert, Cardiovasc. Res. 29, 717 (1995).

Pyranine CAS Registry Number: 6358-69-6; 27928-00-3 (free acid) 8-羟基-1,3,6-芘三磺酸三钠

CAS Name: 8-Hydroxy-1,3,6-pyrenetrisulfonic acid trisodium salt
Additional Names: C.I. 59040; C.I. Solvent Green 7; HPTS
Percent Composition: C 36.65%, H 1.35%, Na 13.15%, O 30.51%, S 18.34%
Literature References: Fluorescent dye with pH-sensitive spectral properties. Prepn: E. Tietze, O. Bayer, Ann. 540, 189 (1939). Use as a pH probe for liposome interiors: K. Kano, J. H. Fendler, Biochim. Biophys. Acta 509, 289 (1978); for phospholipid vesicles: N. R. Clement, J. M. Gould, Biochemistry 20, 1534 (1981); in yeast cells: A. Peña et al., J. Bacteriol. 177, 1017 (1995); in organelles: C. C. Overly et al., Proc. Natl. Acad. Sci. USA 92, 3156 (1995); in cytosol: B. S. Gan et al., Am. J. Physiol. Cell Physiol. 275, 1158 (1998). Effects of salt and polyethylene glycol concentration on pKa: Y. Avnir, Y. Barenholz, Anal. Biochem. 347, 34 (2005). Review of use as a biological stain: Conn's Biological Stains, R. W. Horobin, J. A. Kiernan, Eds. (BIOS Scientific Publishers Ltd, Oxford, UK, 10th ed., 2002) 399-400.

Quin2 CAS Registry Number: 73630-23-6 (salt); 83014-44-2 (acid)

CAS Name: N-[2-[[8-[Bis(carboxymethyl)amino]-6-methoxy-2-quinolinyl]methoxy]-4-methylphenyl]-N-(carboxymethyl)glycine tetrapotassium salt
Additional Names: 2-[[2-[bis(carboxymethyl)amino]-5-met...
Literature References: Fluorescent indicator dye which is primarily used for measuring changes in intracellular Ca2+. Increases in ion concn results in increased fluorescence without a shift in wavelengths. Prepn: R. Y. Tsien, Biochemistry 19, 2396 (1980). Use in measuring Ca2+ flow: J. N. Crofts, G. J. Barritt, Biochem. J. 264, 61 (1989); Zn2+-protein interactions: J. R. Jefferson et al., Anal. Biochem. 187, 328 (1990); in fluorescent lifetime imaging of cells: J. R. Lakowicz et al., Cell Calcium 15, 7 (1994). Fluorescent properties of acetoxymethyl ester: N. Miyoshi et al., Appl. Fluoresc. Technol. 4, 3 (1992). Dissociation parameters for Ca2+ and Mg2+ complexes: D. T. W. Bryant, Biochem. J. 226, 613 (1985); and photophysics: V. Van Den Bergh et al., Photochem. Photobiol. 61, 442 (1995). Review of use in measurement of Ca2+: R. Y. Tsien, T. Pozzan, Methods Enzymol. 172, 230-232 (1989).

TSQ CAS Registry Number: 109628-27-5 N-(6-甲氧-8-喹啉基)-P-对甲苯磺酰甲基亚硝酰胺

CAS Name: N-(6-Methoxy-8-quinolinyl)-4-methylbenzenesulfonamide
Additional Names: 6-methoxy-8-(p-toluenesulfonyl)aminoquinoline
Percent Composition: C 62.18%, H 4.91%, N 8.53%, O 14.62%, S 9...
Literature References: Fluorescent membrane permeant probe selective for Zn2+ in the presence of Ca2+ and Mg2+. Prepn: G. B. Bachman et al., J. Org. Chem. 15, 1278 (1950). Atomic absoportion determn of Zn2+ to picomole levels in biological systems: J. G. Reyes et al., Biol. Res. 27, 49 (1994). Structure/mechanism analysis: M. S. Nasir et al., J. Biol. Inorg. Chem. 4, 775 (1999). Visualization of reactive zinc in the brain: C. J. Frederickson et al., J. Neurosci. Methods 20, 91 (1987); in extracellular areas of CNS: A. A. Larson et al., Pain 86, 177 (2000); in apoptosis: G. R. Sauer et al., J. Cell Biochem. 88, 954 (2003).

Epicocconone CAS Registry Number: 371163-96-1

CAS Name: (6S,9aS)-5,6-Dihydro-6-(hydroxymethyl)-3-[(1Z,4E,6E,8E)-1-hydroxy-3-oxo-1,4,6,8-decatetraenyl]-9a-methyl-2H-furo[3,2-g][2]benzopyran-2,9(9aH)-dione
Trademarks: Deep Purple (Amersham B...
Literature References: Fluorescent natural product isolated from the fungus Epicoccum nigrum. Reacts reversibly with primary amines to produce a highly fluorescent enamine. Prepn: P. J. L. Bell, P. Karuso, WO 0181351 (2001 to Maquarie Res. Ltd.); eidem, US 030157518 (2003). Isoln, characterization, and fluorescence applications: eidem, J. Am. Chem. Soc. 125, 9304 (2003). Protein gel staining characteristics: J. A. Mackintosh et al., Proteomics 3, 2273 (2003). Photostability study: G. B. Smejkal et al., Electrophoresis 25, 2511 (2004). Mechanism of protein staining: D. R. Coghlan et al., Org. Lett. 7, 2401 (2005).

Florfenicol CAS Registry Number: 73231-34-2 氟苯尼考

CAS Name: 2,2-Dichloro-N-[(1S,2R)-1-(fluoromethyl)-2-hydroxy-2-[4-(methylsulfonyl)phenyl]ethyl]acetamide
Additional Names: D-(threo)-1-p-methylsulfonylphenyl-2-amino-3-fluoro-1-propanol; fluoro...
Literature References: Fluorinated derivative of thiamphenicol, q.v. Inhibits bacterial protein synthesis by binding to ribosome 50S and 70S subunits. Prepn: T. Nagabhushan, EP 14437; US 4235892 (both 1980 to Schering); D. P. Schumacher et al., J. Org. Chem. 55, 5291 (1990). Improved prepn: G. Wu et al., ibid. 62, 2996 (1997). HPLC determn in fish plasma: C. Vue et al., J. Chromatogr. B 780, 111 (2002). In vitro antibacterial activity: H. C. Neu, K. P. Fu, Antimicrob. Agents Chemother. 18, 311 (1980); V. P. Syriopoulou et al., ibid. 19, 294 (1981); vs bovine and porcine respiratory disease isolates: S. J. Shin et al., Vet. Microbiol. 106, 73 (2005). Pharmacokinetics in veal calves: K. J. Varma et al., J. Vet. Pharmacol. Ther. 9, 412 (1986); in sheep: J. Shen et al., ibid. 27, 163 (2004). Therapeutic effect on pseudotuberculosis in yellowtail tuna: N. Yasunaga, S. Yasumoto, Fish Pathol. 23, 1 (1988).