其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
备注: 根据相关法律法规, 本站点不显示有法律约束管制的产品, 如有遗漏, 请自行鉴别,或提交我们及时更新撤除.
如有产品相关项目调研推广服务, 请致函联系我们

客户展示

其它产品项目整合

Abarelix CAS Registry Number: 183552-38-7 阿巴瑞克

CAS Name: N-Acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-N-methyl-L-tyrosyl-D-asparaginyl-L-leucyl-N6-(1-methylethyl)-L-lysyl-L-prolyl-D-alaninamide<...
Literature References: Decapeptide LH-RH antagonist. Prepn: R. W. Roeske, WO 9640757 (1996 to Indiana Univ. Found.); idem, US 5843901 (1998 to Adv. Res. Technol. Inst.). Pharmacology and suppression of plasma gonadotropins: C. J. Molineaux et al., Mol. Urol. 2, 265 (1998). Clinical comparison with leuprolide in prostate cancer: J. Trachtenberg et al., J. Urol. 167, 1670 (2002). Clinical pharmacology: S. L. Wong et al., Clin. Pharmacol. Ther. 73, 304 (2003); of depot formulation: eidem, J. Clin. Pharmacol. 44, 495 (2004). Review of clinical development: P. Mongiat-Artus, P. Teillac, Expert Opin. Pharmacother. 5, 2171-2179 (2004).

Agmatine CAS Registry Number: 306-60-5 (4-氨基丁基)胍

CAS Name: 4-(Aminobutyl)guanidine
Additional Names: 1-amino-4-guanidobutane
Percent Composition: C 46.13%, H 10.84%, N 43.03%
Literature References: Decarboxylated arginine. Found in pollen of Ambrosia artemisifolia L., Compositae, in ergot, in sponges, in herring sperm, in octopus muscle: F. W. Heyl, J. Am. Chem. Soc. 41, 670 (1919); A. Kossel, Z. Physiol. Chem. 66, 257 (1910); J. L. Irvin, D. W. Wilson, J. Biol. Chem. 127, 565 (1939). Prepn of salts: DE 463576 (1928 to Schering-Kahlbaum AG). Synthesis: A. Kossel, Z. Physiol. Chem. 68, 170 (1910); K. Odo, J. Chem. Soc. Jpn. 67, 132 (1946); K. Dose, Ber. 90, 1251 (1957). Use as marker for tumor cells: F. S. Steven et al., Anticancer Res. 9, 247 (1989); F. S. Steven et al., J. Enzyme Inhib. 4, 63 (1990).

Isophytol CAS Registry Number: 505-32-8 异植物醇

CAS Name: 3,7,11,15-Tetramethyl-1-hexadecen-3-ol
Additional Names: 2,6,10,14-tetramethylhexadec-15-en-14-ol; 2,6,10-trimethyl-14-vinylpentadecan-14-ol
Percent Composition: C 81.01%, H 13.60%...
Literature References: Decompn product of chlorophyll. Synthesis from linalool or citral: Fischer, Löwenberg, Ann. 475, 183 (1929); Karrer et al., Helv. Chim. Acta 26, 1741 (1943); Sarycheva et al., Zh. Obshch. Khim. 28, 647 (1958); Maurit et al., ibid. 32, 2483 (1962); from acetylene: Nazarov et al., ibid. 28, 1444 (1958); Blaha, Weichet, CS 88887 (1959), C.A. 54, 2167c (1960); from pseudoionone and propargyl alcohol: Sato et al., J. Org. Chem. 28, 45 (1963).

Wieland-Gumlich Aldehyde CAS Registry Number: 466-85-3 去乙酰基达波灵碱

CAS Name: (17R)-19,20-Didehydro-17,18-epoxycuran-17-ol
Additional Names: 1-deacetyldiaboline; caracurine VII
Percent Composition: C 73.52%, H 7.14%, N 9.03%, O 10.31%
Literature References: Decompn product of isonitrosostrychnine: Wieland, Kaziro, Ann. 506, 60 (1933). Isoln from Strychnos toxifera Benth., and S. subcordata Spruce, Loganiaceae: Asmis et al., Helv. Chim. Acta 37, 1983 (1954); Penna et al., Gazz. Chim. Ital. 87, 1163 (1957). Identity with caracurine VII: Bernauer et al., Helv. Chim. Acta 41, 1405 (1958). Structure: Deyrup et al., ibid. 45, 2266 (1962). Chemistry of the degradation from strychnine, q.v.: Hymon et al., ibid. 52, 1564-1602 (1969). Synthesis: L. Szabo, O. Clauder, Acta Chim. Acad. Sci. Hung. 95, 85 (1977). 13C-NMR study: E. Wenkert et al., J. Org. Chem. 43, 1099 (1978).

Piloty's Acid CAS Registry Number: 599-71-3 苯磺酰异羟肟酸

CAS Name: N-Hydroxybenzenesulfonamide
Additional Names: benzenesulfohydroxamic acid; N-(phenylsulfonyl)hydroxylamine
Percent Composition: C 41.61%, H 4.07%, N 8.09%, O 27.71%, S 18.51%
Literature References: Decomposes to produce nitroxyl (HNO). Prepn: O. Piloty, Ber. 29, 1559 (1896). Reaction with aldehydes: A. Hassner et al., J. Org. Chem. 35, 1962 (1970). Crystal structure: J. N. Scholz et al., Tetrahedron 45, 7695 (1989). Decompn study: F. T. Bonner, Y. Ko, Inorg. Chem. 31, 2514 (1992).

Ancrod CAS Registry Number: 9046-56-4 安克洛酶

CAS Name: Agkistrodon serine proteinase
Additional Names: Agkistrodon rhodostoma venom proteinaseTrademarks: Arvin (Knoll); Arwin (Knoll); Viprinex (Knoll)
Literature References: Defibrinating enzyme isolated from the venom of the Malayan pit-viper, Agkistrodon rhodostoma Boie (Calloselasma rhodostoma Boie). Glycosylated serine protease composed of 234 amino acid residues; mol wt ~35,400. Cleaves fibrinogen to form soluble, non-cross-linked fibrin and enhances the local release of tissue plasminogen activator, q.v. Isoln: NL 6502120; H. A. Reid et al., US 3657416 (1965, 1972 to Nat. Res. Dev. Corp.); K. E. Chan et al., Br. J. Haematol. 11, 646 (1965). Initial purification: M. P. Esnouf, G. W. Tunnah, ibid. 13, 581 (1967). Improved purification, chemical composition: C. Nolan et al., Methods Enzymol. 45, 205 (1976). Mechanism of action studies: W. R. Bell et al., J. Lab. Clin. Med. 91, 592 (1978); C. R. M. Prentice et al., Br. J. Haematol. 83, 276 (1993). Review of clinical pharmacology and efficacy: K. A. Illig, K. Ouriel, Semin. Vasc. Surg. 9, 303-314 (1996). Review of use in anticoagulant therapy: R. L. Soutar, J. S. Ginsberg, Crit. Rev. Oncol. Hematol. 15, 23-33 (1993); in acute ischemic stroke: R. P. Atkinson, Drugs 54, Suppl. 3, 100-108 (1997).

EMPTA CAS Registry Number: 18005-40-8 O-乙基甲基硫代膦酸酯

CAS Name: Methylphosphonothioic acid O-ethyl ester
Percent Composition: C 25.71%, H 6.47%, O 22.83%, P 22.10%, S 22.88%
Literature References: Degradation product and precursor of VX, inhibits cholinesterase. Prepn: M. I. Kabachnik et al., Dokl. Akad. Nauk SSSR 104, 861 (1955), C.A. 50, 11240a (1956); F. W. Hoffmann et al., J. Am. Chem. Soc. 81, 148 (1959). Structure: H. Christol et al., C.R. Seances Acad. Sci. Ser. C 265, 1511 (1967). NMR: M. Mikolajczyk et al., J. Am. Chem. Soc. 100, 7003 (1978). Mass spec.: E. R. J. Wils, Fresenius J. Anal. Chem. 338, 22 (1990). Ionspray-MS determn in water: R. Kostiainen et al., J. Chromatogr. 634, 113 (1993).

IMPA CAS Registry Number: 1832-54-8 甲基膦酸单异丙酯

CAS Name: Methylphosphonic acid mono(1-methylethyl) ester
Additional Names: iPMPA; O-isopropyl methyl phosphonic acid; neutralized sarin
Percent Composition: C 34.79%, H 8.03%, O 34.76%, P 2...
Literature References: Degradation product of the nerve gas, sarin, q.v. Identification as hydrolysis product: F. C. G. Hoskin, Can. J. Biochem. Physiol. 34, 75 (1956). Prepn as silver salt: idem, Can. J. Chem. 35, 581 (1957); of ester: J. I. G. Cadogan et al., J. Chem. Soc. 1971, 1988. Biodisposition in mice: P. J. Little et al., Toxicol. Appl. Pharmacol. 83, 412 (1986). Biological monitoring in human urine after sarin exposure: M. Minami et al., J. Toxicol. Sci. 23, Suppl. II, 250 (1998). Biodegradation: Y. Zhang et al., Biotechnol. Bioeng. 64, 221 (1999). Determn in ground water by GC with flame photometric detection: G. A. Sega et al., J. Chromatogr. A 790, 143 (1997); LC-MS rapid determn: R. W. Read, R. M. Black, ibid. 862, 169 (1999).

Ebimar® (Evans) CAS Registry Number: 9013-42-7

Additional Names: Polysaccharide C 16
Literature References: Degraded carrageenan. Sulfated polysaccharide, extracted from Chondrus crispus (L.) Stackhouse, Gigartinaceae. Prepn: Anderson, J. Pharm. Pharmacol. 13, 139 (1961); Anderson, Hargreaves, GB 840623 (1960 to Evans Medical).

Norepinephrine CAS Registry Number: 51-41-2 去甲肾上腺素

CAS Name: 4-[(1R)-2-Amino-1-hydroxyethyl]-1,2-benzenediol
Additional Names: (-)-a-(aminomethyl)-3,4-dihydroxybenzyl alcohol; l-3,4-dihydroxyphenylethanolamine; noradrenaline; levarterenol
Tr...
Literature References: Demethylated precursor of epinephrine, q.v. Occurs in animals and man, and is a sympathomimetic hormone of both adrenal origin and adrenergic orthosympathetic postganglionic origin in man. Physiologic review: Malmejac, Physiol. Rev. 44, 186 (1964). It has also been found in plants, e.g., Portulaca olerocea L., Portulacaceae: Fing et al., Nature 191, 1108 (1961). Synthesis of dl-form: Payne, Ind. Chem. 37, 523 (1961). Historic review of synthesis: Loewe, Arzneim.-Forsch. 4, 583 (1954). Resolution of dl-form: Tullar, J. Am. Chem. Soc. 70, 2067 (1948); idem, US 2774789 (1956 to Sterling Drug). Configuration: Pratesi et al., J. Chem. Soc. 1959, 4062. Comprehensive description: C. F. Schwender, Anal. Profiles Drug Subs. 1, 149-173 (1972); T. D. Wilson, ibid. 11, 555-586 (1982).