Ertugliflozin CAS# 1210344-57-2 埃格列净
Ertugliflozin, also known as also known as PF-04971729, is a potent and selective inhibitor of the sodium-dependent glucose cotransporter 2 and clinical candidate for the treatment of type 2 diabetes mellitus. clinical study showed that Ertugliflozin (1-25 mg/day) improved glycaemic control, body weight and blood pressure in patients with T2DM suboptimally controlled on metformin, and was well tolerated.
📌 参考资料/链接：
Reference: Bernhardson, David; Brandt, Thomas A.; Hulford, Catherine A.; Lehner, Richard S.; Preston, Brian R.; Price, Kristin; Sagal, John F.; St. Pierre, Michael J.; Thompson, Peter H.; Thuma, Benjamin. Development of an Early-Phase Bulk Enabling Route to Sodium-Dependent Glucose Cotransporter 2 Inhibitor Ertugliflozin. Org. Process Res. Dev.201418157-65. Publication Date:January 3, 2014. https://doi.org/10.1021/op400289z.
Reference: Bernhardson, David; Brandt, Thomas A.; Hulford, Catherine A.; Lehner, Richard S.; Preston, Brian R.; Price, Kristin; Sagal, John F.; St. Pierre, Michael J.; Thompson, Peter H.; Thuma, Benjamin. Development of an Early-Phase Bulk Enabling Route to Sodium-Dependent Glucose Cotransporter 2 Inhibitor Ertugliflozin. Org. Process Res. Dev.201418157-65. Publication Date:January 3, 2014. https://doi.org/10.1021/op400289z.
📄 详细内容
CAS No. 1210344-57-2 埃格列净Ertugliflozin synthetic routes
Bernhardson, David; Brandt, Thomas A.; Hulford, Catherine A.; Lehner, Richard S.; Preston, Brian R.; Price, Kristin; Sagal, John F.; St. Pierre, Michael J.; Thompson, Peter H.; Thuma, Benjamin. Development of an Early-Phase Bulk Enabling Route to Sodium-Dependent Glucose Cotransporter 2 Inhibitor Ertugliflozin. Org. Process Res. Dev.201418157-65. Publication Date:January 3, 2014. https://doi.org/10.1021/op400289z.
产品链接: CAS No. 1210344-57-2 ››
Bernhardson, David; Brandt, Thomas A.; Hulford, Catherine A.; Lehner, Richard S.; Preston, Brian R.; Price, Kristin; Sagal, John F.; St. Pierre, Michael J.; Thompson, Peter H.; Thuma, Benjamin. Development of an Early-Phase Bulk Enabling Route to Sodium-Dependent Glucose Cotransporter 2 Inhibitor Ertugliflozin. Org. Process Res. Dev.201418157-65. Publication Date:January 3, 2014. https://doi.org/10.1021/op400289z.
产品链接: CAS No. 1210344-57-2 ››