Neratinib Maleate CAS# 915942-22-2 马来酸来那替尼
Neratinib, also known as HKI-272 or PB272, is an orally available, irreversible inhibitor of the HER-2 receptor tyrosine kinase with potential antineoplastic activity. Neratinib binds to the HER-2 receptor irreversibly, thereby reducing autophosphorylation in cells, apparently by targeting a cysteine residue in the ATP-binding pocket of the receptor.
📌 参考资料/链接：
Reference: Chew, Warren; Cheal, Gloria Karen; Lunetta, Jacqueline Francesca. Process for the preparation of substituted 3-cyanoquinolines and intermediates thereof. WO 2006127207. (Assignee Wyeth, John, and Brother Ltd., USA)
Reference: Chew, Warren; Cheal, Gloria Karen; Lunetta, Jacqueline Francesca. Process for the preparation of substituted 3-cyanoquinolines and intermediates thereof. WO 2006127207. (Assignee Wyeth, John, and Brother Ltd., USA)
📄 详细内容
CAS No. 915942-22-2 马来酸来那替尼Neratinib Maleate synthetic routes
Chew, Warren; Cheal, Gloria Karen; Lunetta, Jacqueline Francesca. Process for the preparation of substituted 3-cyanoquinolines and intermediates thereof. WO 2006127207. (Assignee Wyeth, John, and Brother Ltd., USA)
产品链接: CAS No. 915942-22-2 ››
Chew, Warren; Cheal, Gloria Karen; Lunetta, Jacqueline Francesca. Process for the preparation of substituted 3-cyanoquinolines and intermediates thereof. WO 2006127207. (Assignee Wyeth, John, and Brother Ltd., USA)
产品链接: CAS No. 915942-22-2 ››