Flurpiridaz-nonradiolabeled CAS# 863888-33-9 2-叔丁基-4-氯-5-[[4-(2-氟乙氧基甲基)苯基]甲氧基]哒嗪-3-酮

Flurpiridaz (also known as ¹⁸F-flurpiridaz) is a radiolabeled myocardial perfusion imaging agent targeting mitochondrial complex I.. ¹⁸F-Flurpiridaz demonstrated high affinity for mitochondrial complex I, with excellent myocardial uptake and retention. In rat and dog models, heart-to-lung and heart-to-liver uptake ratios exceeded 5:1 at 60 minutes post-injection, indicating superior cardiac specificity. In isolated working rat hearts, it showed >90% first-pass extraction, significantly outperforming ⁹⁹mTc-based agents. PET imaging in pigs revealed clear, high-resolution myocardial images with minimal background interference. Biodistribution studies showed rapid blood clearance and stable myocardial retention up to 2 hours, supporting its suitability for high-contrast cardiac imaging. These results confirmed its potential as a superior perfusion agent for PET imaging. NOTE: we only provide Flurpiridaz-nonradiolabeled.