Dasatinib CAS# 863127-77-9 达沙替尼(一水合物)
Dasatinib, also known as BMS-354825, is an orally bioavailable synthetic small molecule-inhibitor of SRC-family protein-tyrosine kinases. Dasatinib binds to and inhibits the growth-promoting activities of these kinases. Apparently because of its less stringent binding affinity for the BCR-ABL kinase, dasatinib has been shown to overcome the resistance to imatinib of chronic myeloid leukemia (CML) cells harboring BCR-ABL kinase domain point mutations.
📌 参考资料/链接：
Balaji, N.; Sultana, Sayeeda. Trace level determination and quantification of potential genotoxic impurities in dasatinib drug substance by UHPLC/infinity LC. International Journal of Pharmacy and Pharmaceutical Sciences. Department of Chemistry. St. Peter's University. Tamil Nadu, India 600054. Volume 8. Issue 10. Pages 209-216. 2016
Balaji, N.; Sultana, Sayeeda. Trace level determination and quantification of potential genotoxic impurities in dasatinib drug substance by UHPLC/infinity LC. International Journal of Pharmacy and Pharmaceutical Sciences. Department of Chemistry. St. Peter's University. Tamil Nadu, India 600054. Volume 8. Issue 10. Pages 209-216. 2016
📄 详细内容
CAS No. 863127-77-9 达沙替尼(一水合物)Dasatinib synthetic routes
Balaji, N.; Sultana, Sayeeda. Trace level determination and quantification of potential genotoxic impurities in dasatinib drug substance by UHPLC/infinity LC. International Journal of Pharmacy and Pharmaceutical Sciences. Department of Chemistry. St. Peter's University. Tamil Nadu, India 600054. Volume 8. Issue 10. Pages 209-216. 2016
产品链接: CAS No. 863127-77-9 ››
Balaji, N.; Sultana, Sayeeda. Trace level determination and quantification of potential genotoxic impurities in dasatinib drug substance by UHPLC/infinity LC. International Journal of Pharmacy and Pharmaceutical Sciences. Department of Chemistry. St. Peter's University. Tamil Nadu, India 600054. Volume 8. Issue 10. Pages 209-216. 2016
产品链接: CAS No. 863127-77-9 ››