Bedaquiline CAS# 843663-66-1 贝达喹啉
Bedaquiline, also known as TMC207 and R207910, is a diarylquinoline anti-tuberculosis drug, which was discovered by a team led by Koen Andries at Janssen Pharmaceutica. Bedaquiline blocks the proton pump for ATP synthase of mycobacteria. ATP production is required for cellular energy production and its loss leads to cell death, even in dormant or nonreplicating mycobacteria.It is the first member of a new class of drugs called the diarylquinolines. Bedaquiline is bactericidal.
📌 参考资料/链接：
Saga, Yutaka; Motoki, Rie; Makino, Sae; Shimizu, Yohei; Kanai, Motomu; Shibasaki, Masakatsu. Catalytic Asymmetric Synthesis of R207910. Journal of the American Chemical Society. Volume 132. Issue 23. Pages 7905-7907. Journal. (2010).
Saga, Yutaka; Motoki, Rie; Makino, Sae; Shimizu, Yohei; Kanai, Motomu; Shibasaki, Masakatsu. Catalytic Asymmetric Synthesis of R207910. Journal of the American Chemical Society. Volume 132. Issue 23. Pages 7905-7907. Journal. (2010).
📄 详细内容
CAS No. 843663-66-1 贝达喹啉Bedaquiline synthetic routes
Saga, Yutaka; Motoki, Rie; Makino, Sae; Shimizu, Yohei; Kanai, Motomu; Shibasaki, Masakatsu. Catalytic Asymmetric Synthesis of R207910. Journal of the American Chemical Society. Volume 132. Issue 23. Pages 7905-7907. Journal. (2010).
产品链接: CAS No. 843663-66-1 ››
Saga, Yutaka; Motoki, Rie; Makino, Sae; Shimizu, Yohei; Kanai, Motomu; Shibasaki, Masakatsu. Catalytic Asymmetric Synthesis of R207910. Journal of the American Chemical Society. Volume 132. Issue 23. Pages 7905-7907. Journal. (2010).
产品链接: CAS No. 843663-66-1 ››