Selexipag CAS# 475086-01-2 赛乐西帕
Selexipag, also known as ACT-293987 and NS-304, is a a first-in-class orally available selective non-prostanoid IP receptor agonist, which is currently in development by Actelion as a treatment of pulmonary arterial hypertension. Selexipag and its active metabolite, ACT-333679, are agonists at the prostacyclin receptor, which leads to vasodilation in the pulmonary circulation.
📌 参考资料/链接：
Reference: Chen, Fangjun; Deng, Zeping; Cheng, Jia; Xu, Hui; Tang, Liming. Selexipag intermediate 2-(4-bromobutoxy)acetic acid and 2-(4-bromobutoxy)-N-(methylsulfonyl)acetamide, and preparation method of selexipag. CN 108558653. (Hunan Huateng Pharmaceutical Co., Ltd., Peop. Rep. China)
Reference: Chen, Fangjun; Deng, Zeping; Cheng, Jia; Xu, Hui; Tang, Liming. Selexipag intermediate 2-(4-bromobutoxy)acetic acid and 2-(4-bromobutoxy)-N-(methylsulfonyl)acetamide, and preparation method of selexipag. CN 108558653. (Hunan Huateng Pharmaceutical Co., Ltd., Peop. Rep. China)
📄 详细内容
CAS No. 475086-01-2 赛乐西帕Selexipag synthetic routes
Chen, Fangjun; Deng, Zeping; Cheng, Jia; Xu, Hui; Tang, Liming. Selexipag intermediate 2-(4-bromobutoxy)acetic acid and 2-(4-bromobutoxy)-N-(methylsulfonyl)acetamide, and preparation method of selexipag. CN 108558653. (Hunan Huateng Pharmaceutical Co., Ltd., Peop. Rep. China)
产品链接: CAS No. 475086-01-2 ››
Chen, Fangjun; Deng, Zeping; Cheng, Jia; Xu, Hui; Tang, Liming. Selexipag intermediate 2-(4-bromobutoxy)acetic acid and 2-(4-bromobutoxy)-N-(methylsulfonyl)acetamide, and preparation method of selexipag. CN 108558653. (Hunan Huateng Pharmaceutical Co., Ltd., Peop. Rep. China)
产品链接: CAS No. 475086-01-2 ››