Abametapir CAS# 1762-34-1 5 5'-二甲基-2,2'-联吡啶
Abametapir, a metalloproteinase inhibitor, demonstrated potent pediculicidal activity in preclinical studies. In vitro assays showed abametapir lotion (0.74–1% w/v) achieved >95% mortality of Pediculus humanus capitis adults and eggs within 10 minutes of exposure. Ex vivo human hair assays confirmed ovicidal efficacy, with >90% inhibition of egg hatching compared to vehicle controls. Mechanistic studies indicated abametapir disrupted metalloproteinase-dependent processes essential for louse development and egg viability. Toxicology studies in rodents and rabbits showed no significant systemic toxicity at topical doses up to 3% formulation, supporting its advancement into clinical evaluation as a single-application pediculicide.
📌 参考资料/链接：
Reference:High-yield synthesis of 5,5'-dimethyl-2,2'-bipyridine and 5,5''-dimethyl-2,2':6',2''-terpyridine and some bifunctionalization reactions using N-bromosuccinimide. By: Schubert, Ulrich S.; et al, Synthesis (1999), (5), 779-782
Reference:High-yield synthesis of 5,5'-dimethyl-2,2'-bipyridine and 5,5''-dimethyl-2,2':6',2''-terpyridine and some bifunctionalization reactions using N-bromosuccinimide. By: Schubert, Ulrich S.; et al, Synthesis (1999), (5), 779-782
📄 详细内容
CAS No. 1762-34-1 5 5'-二甲基-2,2'-联吡啶Abametapir synthetic routes
Reference:High-yield synthesis of 5,5'-dimethyl-2,2'-bipyridine and 5,5''-dimethyl-2,2':6',2''-terpyridine and some bifunctionalization reactions using N-bromosuccinimide. By: Schubert, Ulrich S.; et al, Synthesis (1999), (5), 779-782
产品链接: CAS No. 1762-34-1 ››
Reference:High-yield synthesis of 5,5'-dimethyl-2,2'-bipyridine and 5,5''-dimethyl-2,2':6',2''-terpyridine and some bifunctionalization reactions using N-bromosuccinimide. By: Schubert, Ulrich S.; et al, Synthesis (1999), (5), 779-782
产品链接: CAS No. 1762-34-1 ››