TMG
Chemical Name: 2-(alpha-D-Glucopyranosyloxymethyl)-2,5,7,8-tetramethyl-3,4-dihydro-2H-1-benzopyran-6-ol
项目整合开发状态: Preclinical
项目研究机构: CCI Corporation (Originator), Kyoto Prefectural University of Medicine (Originator)
合成路线:Reduction of carboxylic acid (Trolox) (I) with LiAlH4 in refluxing diethyl ether affords alcohol (TM) (II).Reaction of (II) in DMSO with maltose (III) and alpha-glucosidase in potassium phosphate buffer yields the final product.
📌 参考资料/链接：
参考文献标题:Chromanol glycoside and method for production thereof
文献作者:Murase,H.; Tsujii,T.; Kunieda,T.(CCI Corporation)
参考来源:US 5478812
📄 详细内容
合成路线:Reduction of carboxylic acid (Trolox) (I) with LiAlH4 in refluxing diethyl ether affords alcohol (TM) (II).Reaction of (II) in DMSO with maltose (III) and alpha-glucosidase in potassium phosphate buffer yields the final product.
参考文献标题:Antioxidant activity of a novel vitamin E derivative,2-(alpha-D-glucopyranosyl)methyl-2,5,7,8-tetramethylchroman-6-ol
文献作者:Murase,H.; et al.
参考来源:Free Radical Biol Med 1998,24(2),217
合成路线:Reduction of carboxylic acid (Trolox) (I) with LiAlH4 in refluxing diethyl ether affords alcohol (TM) (II).Reaction of (II) in DMSO with maltose (III) and alpha-glucosidase in potassium phosphate buffer yields the final product.
参考文献标题:Synthesis of a novel vitamin E derivative,2-(alpha-D-glucopyranosyl)methyl-2,5,7,8-tetramethylchroman-6-ol,by alpha-glucosidase-catalyzed transglycosylation
文献作者:Murase,H.; Yamauchi,R.; Kato,K.; Kunieda,T.; Terao,J.
参考来源:Lipids 1997,32(1),73