新产品编号:1813481

Chemical Name: 8-Chloro-6-methyl-2,3,5,6-tetrahydro-1H-benzo[c]quinolizin-3-one
项目整合开发状态: Biological Testing
项目研究机构: Universit?degli Studi di Firenze (Originator)
合成路线:Lactam (I) was protected as the tert-butyl carbamate (II) by treatment with Boc2O in the presence of Et3N and DMAP.After reduction of (II) with NaBH4 in EtOH at -25 C,reaction with ethanolic HCl produced the ethoxy derivative (III).Treatment with TiCl4 in CH2Cl2 at -30 C generated the intermediate iminium salt (IV),that was converted into the target benzoquinolizinone system (VI) by the tandem Mannich-Michael condensation with 2-(trimethylsilyloxy)-1,3-butadiene (V).Finally,oxidation of (V) with mercuric acetate produced the desired unsaturated compound.