新产品编号:1810317
Chemical Name: 3-[2-(4-Methoxyphenyl)-2-oxoethyl]-5-(4-oxo-2-phenyl-4H-1-benzopyran-6-ylmethylene)thiazolidine-2,4-dione
项目整合开发状态: Biological Testing
项目研究机构: Ankara 躰iversitesi (Originator)
合成路线:Thiazolidinedione (III) was prepared by condensation of chloroacetic acid (I) with thiourea (II).Alkylation of the potassium salt of (III) with 4-methoxyphenacyl bromide (IV) furnished the 3-phenacyl thiazolidinedione (V).Finally,aldol condensation of (V) with flavone-6-carboxaldehyde (VI) in the presence of NaOAc in HOAc provided the title compound.
📌 参考资料/链接:
参考文献标题:Synthesis of 3-substituted phenacyl-5-[2-phenyl-4H-4-oxo-1-benzopyran-6-yl(methylenyl]thiazolidine-2,4-diones and evaluation of their antimicrobial activity
文献作者:Altanlar,N.; Ayhan-Killergil,G.
参考来源:Arzneim-Forsch Drug Res 2000,50(2),154