新产品编号:1808735
Chemical Name: 5-(1-Piperidinyl)-5H-1-benzopyran[4,3-d]pyrimidin-2-amine
项目整合开发状态: Preclinical
项目研究机构: Universit?degli Studi di Genova (Originator), Universit?degli Studi di Parma (Originator)
合成路线:3-Formylchromen-4-one (II) was prepared by Vilsmeier formylation of 2'-hydroxyacetophenone (I) with POCl3 and DMF.Cyclization of (II) with guanidine carbonate (III) in refluxing EtOH gave rise to the benzopyranopyrimidine (IV).This was finally condensed with piperidine (V) in the presence of TiCl4 to furnish the title compound.
📌 参考资料/链接：
参考文献标题:Synthesis and pharmacological screening of novel non-acidic gastroprotective antipyretic anti-inflammatory agents with anti-platelet properties.5-Alkyl/cycloalkylamino substituted 2-amino-5H-[1]benzopyrano[4,3-d]pyrimidines
文献作者:Barocelli,E.; Bertoni,S.; Bruno,O.; Ranise,A.; Schenone,S.; Chiavarini,M.; Ballabeni,V.
参考来源:Arzneim-Forsch Drug Res 2000,50(2),140