新产品编号:1805571
Chemical Name: 9-[5(S)-Hydroxy-4(R)-(hydroxymethyl)-2-cyclohexen-1(S)-yl]guanine
项目整合开发状态: Biological Testing
项目研究机构: Rega Institute for Medical Research (Originator)
合成路线:Coupling of known allylic alcohol (I) with 2-amino-6-chloropurine (II) under Mitsunobu conditions furnished nucleoside (III).Subsequent desilylation and chloride hydrolysis by means of aqueous trifluoroacetic acid yielded the title compound.
📌 参考资料/链接：
参考文献标题:The cyclohexene ring system as a furanose mimic: Synthesis and antiviral activity of both enantiomers of cyclohexenylguanine
文献作者:Wang,J.; Froeyen,M.; Hendrix,C.; Andrei,G.; Snoeck,R.; De Clercq,E.; Herdewijn,P.
参考来源:J Med Chem 2000,43(4),736