新产品编号:1803989
Chemical Name: 1-(3,4-Dichlorobenzyl)-3,4-dihydro-1H-2,1,3-benzothiadiazin-4-one S,S-dioxide
项目整合开发状态: Biological Testing
项目研究机构: Almirall Prodesfarma (Originator), CSIC (Originator)
合成路线:Benzothiadiazine S,S-dioxide (II) was obtained by a two-step condensation of methyl anthranylate (I) and sulfamoyl chloride following a reported procedure (1).The alkylation of (II) with 3,4-dichlorobenzyl chloride (III) in the presence of NaHCO3 furnished the title compound.
📌 参考资料/链接：
参考文献标题:Benzyl derivatives of 2,1,3-benzo- and benzothieno[3,2-a]thiadiazine 2,2-dioxides: First phosphodiesterase 7 inhibitors
文献作者:Mart韓ez,A.; Castro,A.; Gil,C.; Miralpeix,M.; Segarra,V.; Domenech,T.; Beleta,J.; Palacios,J.M.; Ryder,H.; Miro,X.; Bonet,C.; Casacuberta,J.M.; Azorin,F.; Pina,B.; Puigdomenech,P.
参考来源:J Med Chem 2000,43(4),683
📄 详细内容
合成路线:Benzothiadiazine S,S-dioxide (II) was obtained by a two-step condensation of methyl anthranylate (I) and sulfamoyl chloride following a reported procedure (1).The alkylation of (II) with 3,4-dichlorobenzyl chloride (III) in the presence of NaHCO3 furnished the title compound.
参考文献标题:
文献作者:
参考来源:J Am Chem Soc 1962,841994-2000