新产品编号:1802407

Chemical Name: 2,3,7,8,9,11-Hexahydro-1H-pyrrolo[1,2-a]pyrrolo[1',2':1,2]imidazo[4,5-f]benzimidazole-5,10-dione
项目整合开发状态: Biological Testing
项目研究机构: Arizona State University (Originator)
合成路线:Treatment of 1,5-dibromo-2,4-dinitrobenzene (I) with pyrrolidine (II) afforded dipyrrolidino derivative (III).Reduction of the nitro groups of (III) by catalytic hydrogenation,followed by acetylation of amine (IV) provided diamide (V).Oxidative cyclization of (V) using H2O2 in the presence of formic acid gave rise to the dipyrroloimidazobenzimidazole system (VI).Quinone elaboration involved nitration of (VI) to (VII),nitro group reduction to amine (VIII),and finally amine oxidation employing Fremy's salt.