CTDP-31677
Chemical Name: 1-(3,4-Dichlorophenyl)-1-[4(S)-(3,4-dichlorophenyl)-4-hydroxy-1-methylpiperidin-3(R)-yl]methanone
项目整合开发状态: Preclinical
项目研究机构: Georgetown University (Originator), UT Medical Branch at Galveston (Originator)
合成路线:The title compound was synthesized by acid-catalyzed condensation of 3',4'-dichloroacetophenone (I) with paraformaldehyde and methylamine.
📌 参考资料/链接：
参考文献标题:Discovery of a novel dopamine transporter inhibitor,4-hydroxy-1-methyl-4-(4-methylphenyl)-3-piperidyl 4-methylphenyl ketone,as a potential cocaine antagonist through 3D-database pharmacophore searching.Molecular modeling,structure-activity relationshi
文献作者:Wang,S.; Sakamuri,S.; Enyedy,I.J.; Kozikowski,A.P.; Deschaux,O.; Bandyopadhyay,B.C.; Tella,S.R.; Zaman,W.A.; Johnson,K.M.
参考来源:J Med Chem 2000,43(3),351