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新产品编号:1777095

Chemical Name: 8-[3,7-Dimethyl-2(E),6-octadienyl]-3,5,7-trihydroxy-2-[3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-4H-1-benzopyran-4-one
项目整合开发状态: Biological Testing
项目研究机构: Universit?Claude Bernard Lyon 1 (Originator)
合成路线:Commercial silybin (I) was oxidized to dehydrosilybin (II) employing iodine and KOAc in HOAc.Alkylation of (II) with geranyl bromide (III) in the presence of tetraethylammonium hydroxide provided a mixture of the desired 8-geranyl dehydrosilybin along with minor amounts of the 6-geranyl isomer (IV),which were separated by chromatography.
📌 参考资料/链接:
参考文献标题:The flavanolignan silybin and its hemisynthetic derivatives,a novel series of potential modulators of P-glycoprotein
文献作者:Maitrejean,M.; Comte,G.; Barron,D.; El Kirat,K.; Conseil,G.; Di Pietro,A.
参考来源:Bioorg Med Chem Lett 2000,10(2),157