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新产品编号:1761275

Chemical Name: N-[2-(Diethylamino)ethyl]-2-(4-oxo-1,2,3-benzotriazin-3-yl)acetamide
项目整合开发状态: Preclinical
项目研究机构: Universit?degli Studi di Napoli (Originator)
合成路线:Condensation of 1,2,3-benzotriazin-4(3H)-one (I) with ethyl bromoacetate (II) in refluxing butanone afforded the 3-(ethoxycarbonylmethyl) derivative (III).The ethyl ester group of (III) was then converted into the target amide by reaction with N,N-diethylethylenediamine (IV) in hot MeOH
📌 参考资料/链接:
参考文献标题:Preparation and local anaesthetic activity of benzotriazinone and benzoyltriazole derivatives
文献作者:Caliendo,G.; De Nucci,G.; Meli,R.; Mattace Raso,G.; Fiorino,F.; Perissutti,E.; Zanesco,A.; Grieco,P.; Santagada,V.
参考来源:Eur J Med Chem 1999,34(12),1043