新产品编号:1759693

Chemical Name: 2,4-Dihydroxy-3,6-dimethylbenzoic acid 4-(ethoxycarbonyl)-3-hydroxy-2,5-dimethylphenyl ester
项目整合开发状态: Biological Testing
项目研究机构: Universit鋞 Regensburg (Originator), Westf鋖ische Wilhelms-Univ. M黱ster (Originator)
合成路线:Ethyl ester (II) is alkylated with benzyl chloride (I) by means of K2CO3 in acetone to yield 4-benzyloxy derivative (III),which is then hydrolyzed with KOH in H2O/DMSO to provide carboxylic acid (IV).Depside formation between derivative (IV) and ethyl ester (II) by means of trifluoroacetic anhydride in toluene furnishes ethyl benzoate derivative (V),which is finally hydrogenated over Pd/C in AcOEt to yield the target product.