新产品编号:1756529

Chemical Name: 5-[2-(Ethylsulfonyloxy)-1,3-dioxo-2,3-dihydro-1H-isoindol-5-ylamino]-5-oxopentanoic acid methyl ester
项目整合开发状态: Biological Testing
项目研究机构: State University of New Jersey (Originator), University of South Alabama (Originator)
合成路线:Condensation of 4-nitrophthalic anhydride (I) with O-benzyl hydroxylamine in refluxing toluene produced phthalimide (II).Catalytic transfer hydrogenation employing cyclohexene in the presence of Pd/C yielded 4-amino-N-hydroxyphthalimide (III),which was condensed with ethanesulfonyl chloride to give sulfonate (IV).Finally,acylation with acid chloride (V) furnished the title compound.