新产品编号:1754947
Chemical Name: 4-(3-Fluorophenyl)-2-hydroxy-4-oxobut-2(Z)-enoic acid methyl ester
项目整合开发状态: Biological Testing
项目研究机构: GlaxoSmithKline (Originator)
合成路线:By condensation of 3-chloroacetophenone (I) with dimethyl oxalate (II) by means of NaOMe in methanol.
合成路线:By condensation of 3-fluoroacetophenone (I) with dimethyl oxalate (II) by means of NaOMe in methanol.
📌 参考资料/链接：
参考文献标题:Synthesis and SAR of 4-aryl-2-hydroxy-4-oxobut-2-enoic acids esters and 2-amino-4-aryl-4-oxobut-2-enoic acids and esters: Potent inhibitors of kynurenine-3-hydroxylase as potential neuroprotective agents
文献作者:Drysdale,M.J.; Hind,S.L.; Janssen,M.; Reinhard,J.F.Jr.
参考来源:J Med Chem 2000,43(1),123