新产品编号:1753365

Chemical Name: 2-(2-Adamantyl)piperidine
项目整合开发状态: Biological Testing
项目研究机构: National Hellenic Research Foundation (Originator), Rega Institute for Medical Research (Originator), University of Athens (Originator)
合成路线:The condensation of adamantan-2-one (I) with 2-pyridyllithium (II) in THF/ethyl ether gives 2-(2-pyridyl)adamantan-2-ol (III),which is treated with dry HCl in ethanol to yield the pyridinium salt (IV).The hydrogenation of (IV) with H2 over PtO2 in ethanol affords 2-(2-piperidinyl)adamantan-2-ol (V),which is treated with SOCl2 in refluxing dichloromethane to provide the piperidinium chloride (VI).The dehydrochlorination of (VI) with KOH in refluxing ethanol yields the tetrahydropyridine (VIII),which is finally hydrogenated with NaBH4 in methanol.