新产品编号:1747037

Chemical Name: (3R,5aS,6R,8aS,9R,10R,12R,12aR)-10-[2-(2-Fluorobenzyloxy)ethyl]-3,6,9-trimethylperhydro-3,12-epoxypyrano[4,3-j]-1,2-benzodioxepine; 10beta-[2-(2-Fluorobenzyloxy)ethyl]-10-deoxoartemisinin
项目整合开发状态: Preclinical
项目研究机构: University of Liverpool (Originator)
合成路线:Coupling of dihydroartemisinin (I) with allyl trimethylsilane in the presence of boron trifluoride etherate gave the 10beta-allyl deoxo derivative (II).Subsequent ozonization of the allyl double bond of (II),followed by reductive treatment with NaBH4,provided alcohol (III).Finally,alkylation of (III) with 2-fluorobenzyl bromide (IV) in the presence of NaH furnished the corresponding 2-fluorobenzyl ether.