LY-274601((+)-enantiomer), LY-274600

Chemical Name: (-)-2(S)-(Propylamino)-8-(methylthio)-1,2,3,4-tetrahydronaphthalene hydrochloride
项目整合开发状态: Biological Testing
项目研究机构: Lilly (Originator)
合成路线:The cleavage of the butyrate group of N-[8-(butyrylsulfanyl)-1,2,3,4-tetrahydro-2(R)-naphthyl)-N,N-dipropylamine (I) by means of tetrabuylammonium hydroxide in DMF/methanol gives the thiolate (II),which is then methylated with [11C]-methyl iodide to obtain the target compound.

合成路线:The cleavage of the butyrate group of N-[8-(butyrylsulfanyl)-1,2,3,4-tetrahydro-2(R)-naphthyl)-N,N-dipropylamine (I) by means of tetrabuylammonium hydroxide in DMF/methanol gives the thiolate (II),which is then methylated with [3H]-methyl iodide to obtain the target compound.