新产品编号:1705905

Chemical Name: 5-(4-Aminophenyl)-N-methyl-8-oxo-8,9-dihydro-7H-[1,3]dioxolo[4,5-h][2,3]benzodiazepine-7-carboxamide
项目整合开发状态: Preclinical
项目研究机构: Universit?degli Studi di Catanzaro (Originator), Universit?degli Studi di Messina (Originator), Universit?degli Studi di Milano (Originator), Universit?degli Studi di Modena (Originator)
合成路线:Benzophenone (III) was prepared by Friedel-Crafts acylation of methyl 3,4-methylenedioxyphenylacetate (I) with 4-nitrobenzoic acid (II).Subsequent cyclization of (III) with hydrazine gave rise to benzodiazepinone (IV).This was treated with methyl isocyanate in the presence of triethylamine to yield the corresponding urea (V).Finally,the nitro group of (V) was reduced to the title aniline by catalytic hydrogenation using Pd-C.