新产品编号:1693249
Chemical Name: 3-(Ethoxycarbonyl)-5-(ethylsulfanylcarbonyl)-4,6-diethyl-1-methyl-2-phenylpyridinium iodide
项目整合开发状态: Biological Testing
项目研究机构: National Institutes of Health (Originator)
合成路线:Pyridine (V) was prepared by Hantsch synthesis upon condensation of ketothioester (I),aldehyde (II) and enamino ester (III),followed by oxidative aromatization of the resulting dihydropyridine (IV) with chloranil,according to a reported method.N-Alkylation of pyridine (V) with iodomethane in hot nitromethane in a sealed tube under pressure furnished the title pyridinium salt.
📌 参考资料/链接:
参考文献标题:Selective A3 adenosine receptor antagonists: Water-soluble 3,5-diacyl-1,2,4-trialkylpyridinium salts and their oxidative generation from dihydropyridine precursors
文献作者:Xie,R.; Li,A.H.; Ji,X.D.; melman,N.; Olah,M.E.; Stiles,G.L.; Jacobson,K.A.
参考来源:J Med Chem 1999,42(20),4232