PNU-176968

Chemical Name: N-[3-[3-Fluoro-4-(5-thiazolyl)phenyl]-2-oxooxazolidin-5(S)-ylmethyl]acetamide
项目整合开发状态: Preclinical
项目研究机构: Pfizer (Originator)
合成路线:Lithiation of thiazole (I) with butyllithium at -78 C,followed by quenching with chlorotrimethylsilane afforded 2-(trimethylsilyl)thiazole (II).A second lithiation generated the 5-lithio thiazole,which was converted to the stannyl derivative (III) upon reaction with tributylstannyl chloride.Then,palladium-catalyzed coupling of (III) with the iodophenyl oxazolidine (IV) in refluxing dioxan furnished the title compound.