新产品编号:1685339
Chemical Name: 2-[2-(4-Chlorophenyl)-8-methylimidazo[1,2-a]pyridin-3-yl]-N,N-dipropylacetamide
项目整合开发状态: Preclinical
项目研究机构: Universit?degli Studi di Bari (Originator), Universit?degli Studi di Cagliari (Originator)
合成路线:Condensation of carboxylic acid (I) with dipropylamine (II) in the presence of ethyl 1,2-dihydro-2-ethoxy-1-quinolinecarboxylate (EEDQ) yields amide (III),which is then brominated with Br2 in CCl4 to provide derivative (IV).Finally,bromoketoamide (IV) is cyclized with to 3-methyl-2-aminopyridine (V) in DMF to furnish the target product.
📌 参考资料/链接：
参考文献标题:Novel 2-phenylimidazo[1,2-a]pyridine derivatives as potent and selective ligands for peripheral benzodiazepine receptors: Synthesis,binding affinity,and in vivo studies
文献作者:Trapani,G.; Franco,M.; latrofa,A.; Ricciardi,L.; Carotti,A.; Serra,M.; Sanna,E.; Biggio,G.; Liso,G.
参考来源:J Med Chem 1999,42(19),3934