新产品编号:1683757
Chemical Name: 4-(6-Amino-4-oxo-3,4-dihydroquinazolin-3-yl)butanoic acid ethyl ester
项目整合开发状态: Preclinical
项目研究机构: University of California, San Diego (Originator)
合成路线:Condensation of 5-nitroanthranilic acid (I) with formamidine hydrochloride (II) at 210 C generated the quinazolinone (III).Subsequent alkylation of (III) at the 3-N atom with ethyl 4-bromobutyrate (IV) in the presence of K2CO3 in DMF produced the quinazoline-3-butyrate ester (V).Finally,catalytic hydrogenation of the nitro group of (V) using Pd/C yielded the corresponding 6-aminoquinazoline.
📌 参考资料/链接：
参考文献标题:Substituted isoquinolines and quinazolines as potential antiinflammatory agents.Synthesis and biological of inhibitors of tumor necrosis factor alpha
文献作者:Chao,Q.; Deng,L.; Shih,H.; Leoni,L.M.; Genini,D.; Carson,D.A.; Cottam,H.B.
参考来源:J Med Chem 1999,42(19),3860