新产品编号:1679011
Chemical Name: 4-Amino-5-chloro-2-methoxy-N-[1-[2-(methylsulfonamido)ethyl]piperidin-4-ylmethyl]benzamide oxalate
项目整合开发状态: Preclinical
项目研究机构: Mitsubishi Pharma (Originator)
合成路线:4-Amino-5-chloro-2-methoxybenzoic acid (I) was coupled to 4-(aminomethyl)-1-[2-(methylsulfonylamino)ethyl]piperidine (II) employing 1-ethyl-3-[3-(dimethylamino)propyl]carbodiimide hydrochloride and 1-hydroxybenzotriazole.The resulting compound was then treated with oxalic acid to provide the corresponding oxalate salt.
📌 参考资料/链接:
参考文献标题:Synthesis and pharmacological evaluation of carboxamide derivatives as selective serotoninergic 5-HT4 receptor agonists
文献作者:Itoh,K.; kanzaki,K.; Ikebe,T.; Kuroita,T.; Tomozane,H.; Sonda,S.; Sato,N.; Haga,K.; Kawakita,T.
参考来源:Eur J Med Chem 1999,34(11),977