新产品编号:1671101

Chemical Name: N-[2-[2-[Bis(4-fluorophenyl)methoxy]ethylamino]ethyl]-3-(4-bromophenyl)-2(E)-propenamide
项目整合开发状态: Preclinical
项目研究机构: Massachusetts General Hospital (Originator), Northeastern University (Originator)
合成路线:The precursor bromoether (III) was prepared by condensation of 4,4?difluorobenzhydrol (I) with 2-bromoethanol (II) under acidic conditions.Treatment of 4-bromocinnamic acid (IV) with thionyl chloride afforded acid chloride (V),which was coupled with ethylenediamine (VI) to furnish mono amide (VII).The title compound was finally obtained by alkylation of amine (VII) with bromide (III) in the presence of K2CO3.