新产品编号:1661609

Chemical Name: 2-(3-Pentyl-3H-1,2-diaziren-3-yl)ethanol
项目整合开发状态: Preclinical
项目研究机构: Harvard Medical School (Originator), Massachusetts General Hospital (Originator), UCLA School of Medicine (Originator)
合成路线:The protection of the OH group of 2-hydroxyacetonitrile (I) with TBDMS-Cl and imidazole in THF gives the silyl ether (II),which is treated with pentylmagnesium bromide (III) in ethyl ether yielding the protected 1-hydroxyoctan-3-one (IV),which is deprotected with HCl in methanol/water affording the corresponding hydroxyketone (V).Finally,this compound is treated with hydroxylamine-O-sulfonic acid in liquid ammonia.