AGR-129
Chemical Name: N-(3-Chlorobenzyl)-2-cyano-3-[2-[3-(1H-imidazol-2-ylsulfanyl)propoxy]phenyl]-2(E)-propenamide
项目整合开发状态: Biological Testing
项目研究机构: Hebrew University (Originator)
合成路线:Salicylaldehyde (I) was alkylated with 1,3-dibromopropane (II) to provide bromopropyl ether (III).Furter displacement of the bromine of (III) with the potassium salt of 2-mercaptoimidazole (IV) gave thioether (V).Condensation of methyl cyanoacetate (VI) with 3-chlorobenzylamine (VII) at 120 C afforded cyanoacetamide (VIII).Finally,Knoevenagel reaction of (VIII) with benzaldehyde (V) in the presence of beta-alanine furnished the title compound.
📌 参考资料/链接：
参考文献标题:alpha-Cyanocinnamide derivatives: A new family of non-peptide,non-sulfhydryl inhibitors of Ras farnesylation
文献作者:Poradosu,E.; Gazit,A.; Reuveni,H.; Levitzki,A.
参考来源:Bioorg Med Chem 1999,7(8),1727