新产品编号:1655281

Chemical Name: N2-[4-(4-Bromophenoxy)phenylsulfonyl]-N1-hydroxy-D-tert-leucinamide
项目整合开发状态: Preclinical
项目研究机构: Agouron (Originator)
合成路线:Chlorosulfonation of 4-bromodiphenyl ether (I) in cold CH2Cl2 afforded the corresponding sulfonyl chloride (II).After silylation of D-tert-leucine (III) with chlorotrimethylsilane and N-methylmopholine,coupling with acid chloride (II) provided sulfonamide (IV).Conversion of (IV) to acid chloride (V) was then achieved by treatment with oxalyl chloride and a catalytic amount of DMF at low temperature.Finally,condensation of (V) with hydroxylamine in aqueous THF gave rise to the target hydroxamic acid.