新产品编号:1647371

Chemical Name: 1-(2,4-Dichlorophenyl)-1-[4-[N-methyl-N-(1-naphthylmethyl)aminomethyl]phenyl]methanone
项目整合开发状态: Biological Testing
项目研究机构: Second Military Medical University (Originator)
合成路线:The intermediate naphthylmethyl amine (IV) was prepared from 1-naphthaldehyde (I) by two related procedures.Reduction of (II) with NaBH4 gave alcohol (II),which was converted to the corresponding chloride with SOCl2 and then condensed with methylamine.Alternatively,condensation of aldehyde (I) with methylamine using TiCl4 as the dehydrating reagent produced aldimine (III),which was then reduced to amine (IV) by means of NaBH4.

合成路线:2,4-Dichlorobenzoic acid (V) was converted to acid chloride (VI) using SOCl2.Further Friedel-Crafts condensation of (VI) with toluene in the presence of AlCl3 produced benzophenone (VII).Benzylic bromination of (VII) with N-bromosuccinimide gave bromide (VIII).Finally,displacement of the bromine of (VIII) by means of amine (IV) furnished the title compound.