Ro-65-7674

Chemical Name: 2-(Methylsulfanyl)-3-(phenylsulfonyl)-8-(piperazin-1-yl)-6,7-dihydro-5H-cyclopenta[d]pyrazolo[1,5-a]pyrimidine
项目整合开发状态: Preclinical
项目研究机构: Roche (Originator)
合成路线:Condensation of ethyl cyclopentanone-2-carboxylate (I) with pyrazolyl amine (II) in boiling AcOH produced pyrazolopyrimidinol (III),which was then chlorinated by means of POCl3 to give (IV).Finally,displacement of the chlorine atom of (IV) with piperazine in hot DMF furnished the title compound.