DF-1
Chemical Name: 3-[(3R,9S,9aR)-9-Hydroxy-4,4-dimethyl-2-oxoperhydroquinolizin-3-yl]quinazolin-4(3H)-one
项目整合开发状态: Preclinical
项目研究机构: Okayama University (Originator), Tohoku College of Pharmacy (Originator), Tohoku University (Originator)
合成路线:By cyclization of febrifugine (I) with acetone over SiO2.
合成路线:The isomerization of febrifugine (I) by means of HCl in methanol gives isofebrifugine (II),which is then cyclized with acetone over SiO2.
📌 参考资料/链接：
参考文献标题:New type of febrifugine analogues,bearing a quinolizidine moiety,show potent antimalarial activity against Plasmodium malaria parasite
文献作者:Takaya,Y.; Tasaka,H.; Chiba,T.; Uwai,K.; Tanitsu,M.; Kim,H.S.; Wataya,Y.; Miura,M.; Takeshita,M.; Oshima,Y.
参考来源:J Med Chem 1999,42(16),3163