Org-13011

Chemical Name: 1-[4-[4-[4-(Trifluoromethyl)pyridin-2-yl]piperazin-1-yl]butyl]pyrrolidin-2-one fumarate
项目整合开发状态: Phase II
项目研究机构: Akzo Nobel (Originator), Organon (Originator)
合成路线:Alkylation of 2-pyrrolidinone (I) with 1,4-dibromobutane (II) in the presence of KOH and tetraethylammonium bromide gave the N-(4-bromobutyl)pyrrolidinone (III).This was condensed with 1-[4-(trifluoromethyl)-2-pyridinyl]piperazine (IV) in the presence of Na2CO3 to produce the target disubstituted piperazine,which was then converted to the corresponding fumarate salt.