WAY-121006
Chemical Name: 2-[2-Fluoro-4'-(quinolin-2-ylmethoxy)biphenyl-4-yl]acetic acid
项目整合开发状态: Biological Testing
项目研究机构: Wyeth Pharmaceuticals (Originator)
合成路线:By condensation of 1-naphthol (I) with 2-(chloromethyl)quinoline (II) by means of NaH in DMF.
合成路线:By condensation of 2(S)-(6-hydroxy-2-naphthyl)propionic acid (I) with 2-(chloromethyl)quinoline (II) by means of NaH in DMF.
合成路线:By condensation of 2-(2-fluoro-4'-hydroxybiphenyl-4-yl)acetic acid (I) with 2-(chloromethyl)quinoline (II) by means of NaH in DMF.
📌 参考资料/链接：
参考文献标题:Conversion of a cyclooxygenase (CO) inhibitor into a 5-lipoxygenase (LO) inhibitor - A general route to novel antiinflammatory and antiallergy drugs
文献作者:Kreft,A.F.; Failli,A.; Musser,J.H.; et al.
参考来源:Drugs Exp Clin Res 1991,17381-387
📄 详细内容
合成路线:By condensation of 1-naphthol (I) with 2-(chloromethyl)quinoline (II) by means of NaH in DMF.
合成路线:By condensation of 2(S)-(6-hydroxy-2-naphthyl)propionic acid (I) with 2-(chloromethyl)quinoline (II) by means of NaH in DMF.
合成路线:By condensation of 2-(2-fluoro-4'-hydroxybiphenyl-4-yl)acetic acid (I) with 2-(chloromethyl)quinoline (II) by means of NaH in DMF.
参考文献标题:Structure -activity relationships in the quinoline- containing class of inhibitors of 5-lipoxygenase (5-LO) enzyme translocation and activation
文献作者:Marshall,L.A.; Wong,A.; Kreft,A.F.
参考来源:Drugs Fut 1994,19(3),255