BBR-2550, NSC-637823-T/1, Na[trans-RuCl4(DMSO)Im].2DMSO
Chemical Name: trans-(Dimethylsulfoxide)(imidazole)tetrachlororuthenium(III) sodium salt bis(dimethylsulfoxide)
项目整合开发状态: Preclinical
项目研究机构: Roche (Originator)
合成路线:The title complex can be obtained from hydrated RuCl3 in three steps.Commercially available ruthenium trichloride is first reacted with a warm mixture of DMSO and HCl to give (DMSO)2H[trans-RuCl4(DMSO)2],which is then transformed into the corresponding sodium salt.The latter is reacted with imidazole in DMSO/acetone to give Na[trans-RuCl4(DMSO)(Im)]2DMSO.Acetone and,sometimes,water molecules can partially replace the DMSO molecules of crystallization.
📌 参考资料/链接：
参考文献标题:Synthesis,molecular structure and chemical behavior of hydrogen trans-bis(DMSO)tetrachlororuthenate(III) and mer-trichlorotris(DMSO)ruthenium(III): The first full characterized chloride-dimethyl sulfoxide-ruthenium(III) complexes
文献作者:Attia,W.M.; Calligaris,M.; Costa,G.; Balducci,G.; Mestroni,G.; Alessio,E.
参考来源:Inorg Chem 1991,30(4),609-18
📄 详细内容
合成路线:The title complex can be obtained from hydrated RuCl3 in three steps.Commercially available ruthenium trichloride is first reacted with a warm mixture of DMSO and HCl to give (DMSO)2H[trans-RuCl4(DMSO)2],which is then transformed into the corresponding sodium salt.The latter is reacted with imidazole in DMSO/acetone to give Na[trans-RuCl4(DMSO)(Im)]2DMSO.Acetone and,sometimes,water molecules can partially replace the DMSO molecules of crystallization.
参考文献标题:Na[trans-RuCl4(DMSO)Im].2DMSO
文献作者:Mestroni,G.; Pacor,S.; Coluccia,M.; Alessio,E.; Sava,G.; Cocchietto,M.; Gagliardi,R.
参考来源:Drugs Fut 1993,18(10),894
合成路线:The title complex can be obtained from hydrated RuCl3 in three steps.Commercially available ruthenium trichloride is first reacted with a warm mixture of DMSO and HCl to give (DMSO)2H[trans-RuCl4(DMSO)2],which is then transformed into the corresponding sodium salt.The latter is reacted with imidazole in DMSO/acetone to give Na[trans-RuCl4(DMSO)(Im)]2DMSO.Acetone and,sometimes,water molecules can partially replace the DMSO molecules of crystallization.
参考文献标题:Synthesis and characterization of two new classes of ruthenium(III)-sulfoxide complexes with nitrogen donor ligands (L): Na[trans-RuCl4(R2SO)(L)] and mer,cis-RuCl3(R2SO3)2(L)
文献作者:Calligaris,M.; Mestroni,G.; Balducci,G.; Attia,W.M.; Alessio,E.; Lutman,A.
参考来源:Inorg Chim Acta 1993,203205-17