新产品编号:1623641
Chemical Name: 2-(3-Benzoyl-4-cyclohexyl-1,4-dihydropyridin-1-yl)propionamide
项目整合开发状态: Preclinical
项目研究机构: University of Alberta (Originator), University of Calgary (Originator)
合成路线:Alkylation of 3-benzoylpyridine (I) with methyl 2-bromopropionate (II) in refluxing acetone afforded pyridinium salt (III).The subsequent regiospecific copper-catalyzed condensation of (III) with cyclohexylmagesium chloride (IV) yielded dihydropyridine (V).Finally,ammonolysis of the methyl acetate ester of (V) provided the title amide.
📌 参考资料/链接：
参考文献标题:Synthesis and analgesic activity of 2-methyl-2-[1-(3-benzoyl-4-substituted-1,4-dihydropyridyl)]acetic acid methyl esters,acetic acids,and acetamides
文献作者:Agudoawu,S.A.; et al.
参考来源:Arch Pharm 1999,332(6),213