新产品编号:1622059

Chemical Name: N-Benzyl-9-isopropyl-2-(thiomorpholin-4-yl)-9H-purin-6-amine
项目整合开发状态: Biological Testing
项目研究机构: LG Chem (Originator)
合成路线:Adenine (I) was oxidized with hydrogen peroxide in aqueous acetic acid to give adenine 1-N-oxide (II).Diazotization of (II) with sodium nitrite and acetic acid,followed by hydrolysis of the diazonium salt provided hypoxanthine 1-N-oxide (III).2,6-Dichloropurine (IV) was then obtained by treatment of (III) with phosphoryl chloride in the presence of triethylamine.Displacement of the 6-chlorine atom of (IV) by benzylamine (V) in boiling n-butanol yielded 6-benzylamino-2-chloropurine (VI),which was subsequently alkylated at the 9-N with isopropyl iodide and NaH to give (VII).Finally,the remaining 2-chloro atom of (VII) was displaced by thiomorpholine (VIII) to furnish the title compound.