新产品编号:1615731
Chemical Name: N-[4-[3-[1(S),3-Dicarboxypropyl]ureido]benzyloxycarbonyl]doxorubicin
项目整合开发状态: Biological Testing
项目研究机构: Cancer Research UK (Originator)
合成路线:Coupling of 4-aminobenzyl alcohol (I) with diallyl L-glutamylisocyanate (II) produced the urea derivative (III).Subsequent activation of the benzylic alcohol group with 4-nitrophenyl chloroformate (IV) afforded carbonate (V).This was then condensed with doxorubicin (VI) to furnish the corresponding carbamate (VII).Finally,palladium-catalyzed cleavage of the allyl esters of (VII) yielded the title compound.
📌 参考资料/链接：
参考文献标题:Self-immolative anthracycline prodrugs for suicide gene therapy
文献作者:Niculescu-Duvaz,I.; Niculescu-Duvaz,D.; Friedlos,F.; Spooner,R.; Martin,J.; Marais,R.; Springer,C.J.
参考来源:J Med Chem 1999,42(13),2485