新产品编号:1566689
Chemical Name: 1-(4-Chlorophenyl)-3-(hydroxymethyl)-9H-pyrido[3,4-b]indole
项目整合开发状态: Preclinical
项目研究机构: Central Drug Research Institute (Originator)
合成路线:Esterification of L-tryptophan (I) by means of MeOH and SOCl2 gave the corresponding methyl ester (II).Subsequent Pictet-Spengler cyclization of (II) with 4-chlorobenzaldehyde (III) furnished the tetrahydropyridoindole (IV),which was dehydrogenated to the beta-carboline (V) using sulfur in refluxing xylene.The ester group of (V) was finally reduced to the target alcohol with LiAlH4 in THF.
📌 参考资料/链接：
参考文献标题:Potent 1,3-disubstituted-9H-pyrido[3,4-b]indoles as new lead compounds in antifilarial chemotherapy
文献作者:Srivastava,S.K.; Agarwal,A.; Chauhan,P.M.; Agarwal,S.K.; Bhaduri,A.P.; Singh,S.N.; Fatima,N.; Chatterjee,R.K.
参考来源:J Med Chem 1999,42(9),1667
📄 详细内容
合成路线:Esterification of L-tryptophan (I) by means of MeOH and SOCl2 gave the corresponding methyl ester (II).Subsequent Pictet-Spengler cyclization of (II) with 4-chlorobenzaldehyde (III) furnished the tetrahydropyridoindole (IV),which was dehydrogenated to the beta-carboline (V) using sulfur in refluxing xylene.The ester group of (V) was finally reduced to the target alcohol with LiAlH4 in THF.
参考文献标题:Potent 1,3-disubstituted-9H-pyrido[3,4-b]indoles as new lead compounds in antifilarial chemotherapy
文献作者:Srivastava,S.K.; Agarwal,A.; Chauhan,P.M.; Agarwal,S.K.; Bhaduri,A.P.; Singh,S.N.; Fatima,N.; Chatterjee,R.K.
参考来源:Bioorg Med Chem 1999,7(6),1223