S-22575, PMS-889
Chemical Name: 2-(4,5-Dihydro-1H-imidazol-2-yl)-1,4-bis(2-methylpropyl)piperazine
项目整合开发状态: Preclinical
项目研究机构: Servier (Originator)
合成路线:Alkylation of ethyl piperazine-2-carboxylate (I) with two equivalents of isopropyl iodide (II) afforded disubstituted piperazine (III).The title imidazoline was then obtained by reaction of the ester function of (III) with ethylenediamine (IV) in the presence of trimethylaluminum.
合成路线:Alkylation of ethyl piperazine-2-carboxylate (I) with two equivalents of isobutyl bromide (II) under catalysis of KI afforded disubstituted piperazine (III).The title imidazoline was then obtained by reaction of the ester function of (III) with ethylenediamine (IV) in the presence of trimethylaluminum.
📌 参考资料/链接：
参考文献标题:Design and synthesis of imidazoline derivatives active on glucose homeostasis in a rat model of type II diabetes.2.Syntheses and biological activities of 1,4-dialkyl-,1,4-dibenzyl,and 1-benzyl-4-alkyl-2-(4',5'-dihydro-1'H-imidazol-2'-yl)piperazines an
文献作者:Le Bihan,G.; Rondu,F.; Pele-Tounian,A.; Wang,X.; Lidy,S.; Touboul,E.; Lamouri,A.; Dive,G.; Huet,J.; Pfeiffer,B.; Renard,P.; Guardiola-Lemaitre,B.; Manechez,D.; Penicaud,L.; Ktorza,A.; Godfroid,J.J.
参考来源:J Med Chem 1999,42(9),1587