新产品编号:1565107
Chemical Name: 1',2,3,3',4,4',5,5',6',7',7,8,8',9,9',10,10'-Heptadecahydro-6-mercapto-1,2'-bisdecaborate(4-) tetrasodium salt
项目整合开发状态: Preclinical
项目研究机构: Southwest Texas State University (Originator), University of California, Los Angeles (Originator)
合成路线:The reaction of the normal isomer of eicosaborohydride anion (I) with potassium tert-butyl thiocarbonate (II) in refluxing THF produced the unexpected apical-apical isomer of the thiocarbonate borane (III).Acid cleavage of the thiocarbonate group afforded the target thiol derivative,which was isolated as the tetrasodium salt after treatment with an ion-exchange resin.
📌 参考资料/链接：
参考文献标题:Synthesis and in vivo murine evaluation of Na4[1-(1'-B10H9)-6-SHB10H8] as a potential agent for boron neutron capture therapy
文献作者:Feakes,D.A.; Waller,R.C.; Hathaway,D.K.; Morton,V.S.
参考来源:Proc Natl Acad Sci USA 1999,96(11),6406